Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.

Tchuenmogne, Aimee M. T.; Donfack, Erik V.; Kongue, Michel D. T.; Lenta, Bruno N.; Ngouela, Silvère; Tsamo, Etienne; Sidhu, Navdeep Singh; Dittrich, Birger; Laatsch, Hartmut

doi:10.5012/bkcs.2013.34.12.3859

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…It is worth noting that this is the first report of a CG-MS analysis of hexanic extracts from Inga jinicuil . However, similar studies have been documented for other species of the Inga genus; such is the case for I. edulis , where triterpene compounds including lupeol and stigmasterol, as well as aliphatic compounds, have been identified from extracts of the bark and leaves [ 33 , 34 ]. Likewise, extracts from the bark and leaves of I. laurina have shown the presence of terpenes such as phytol, the aliphatic nonacosane, and esterified aliphatic acids [ 35 ], whereas in a hexanic fraction obtained from the leaves of I. semialata , the main compounds isolated were triterpenes, such as lupeol, α-amyrin, oleanolic acid, and friedelin [ 30 ].…”

Section: Resultssupporting

confidence: 60%

“…Likewise, other studies on leaf extracts from I. edulis , reported the presence of four triterpenes (lupeol, α-amirin, olean-18-ene acid, and frideline), three flavonoids, eight phenolic acids, an anthocyanin derived from delphinidin-3-glycoside, and a mixture of five acylated anthocyanins. It is important to highlight the fact that gallic acid, methyl gallate, protocatechuic acid, and quercetin were also identified [ 33 ]. For I. laurina , there is a presence of flavonoids 3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside in leaf extracts [ 19 ], as well as gallic acid, myricetin derivatives, quercetin glycoside, and glycoside myricetin-3-O-rhamnosid from ethanolic extracts of leaves from this plant [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

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Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Gallegos-García

Lobato‐García

González-Cortazar

et al. 2022

Plants

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Several Mesoamerican cultures have used Inga jinicuil as traditional medicine for the treatment of gastrointestinal, inflammatory, and infectious issues. The aims of this contribution were to elucidate the phytochemical profile of the organic extracts from the bark and leaves of I. jinicuil and to assess the anti-inflammatory and antibacterial properties of these extracts. The preliminary chemical profile was determined by HPLC-PDA and GC-MS; the anti-inflammatory activity was evaluated with a mouse ear edema model, whereas the antibacterial activity was screened against several bacteria. The phytochemical profile of both organs (bark and leaves) of I. jinicuil led to the identification of 42 compounds, such as polyphenolic, flavonoids, triterpenes, prenol-type lipids, and aliphatic and non-aliphatic esters. This molecular diversity gave moderate anti-inflammatory activity (67.3 ± 2.0%, dichloromethane bark extract) and excellent antibacterial activity against Pseudomona aeruginosa and methicillin-resistant Sthaphylococcus aureus (MIC values of ˂3.12 and 50 µg/mL, respectively). These results contribute to the chemotaxonomic characterization and the rational use in traditional medicine of Inga jinicuil Schltdl & Cham. ex G. Don.

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Section: Resultssupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Gallegos-García

Lobato‐García

González-Cortazar

et al. 2022

Plants

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“…Differences between results of these experiments can be caused by dissimilar response of cancer cells to active compounds present in I. edulis as it has previously been observed for various classes of natural compounds (Sak, 2014). Since the kojic acid, recently found in leaves of I. edulis (Tchuenmogne et al, 2013), have exerted significant antioxidant as well as anti-proliferative activities (Novotny et al, 1999;Kusumawati and Indrayanto, 2013) it might considerably contribute to combined biological effect of the plant.…”

Section: Discussionmentioning

confidence: 82%

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Tauchen

Bortl

Huml

et al. 2016

Revista Brasileira de Farmacognosia

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Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 +/- 51.4 mu g TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 mu g/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 mu g/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 mu g TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 mu g/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases

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“…Previous studies with the genus Inga have shown that phenolic compounds are present in the leaves of Inga umbellifera and Inga goldmani (LOKVAM; COLEY; KURSAR, 2004), in addition to Inga edulis leaves (NASCIMENTO; SOBRINHO; SOUZA; De SOUZA; SOUSA, 2021). From the leaves and bark of the species Inga edulis, phenolic compounds and flavonoids have also been isolated and their antioxidant capacity evaluated (DIAS; SOUZA; ROGEZ, 2010;TCHUENMOGNE et al, 2013). In fruit and vegetable residues, for example, seeds are commonly discarded despite having excellent nutritional and functional characteristics.…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds, antimicrobial activity, cytotoxicity, and identification of phytochemicals present in Inga marginata Willd seeds

Flores

Boeira

Rolim

et al. 2021

CeN

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Brazil has an invaluable source of plants and fruits rich in phenolic compounds important to health, some of which have yet to be discovered. Inga marginata Willd is a fruit that can be found throughout Brazil, and its seeds are rich in phenolic compounds and antimicrobial activity, thus making their extraction and characterization highly relevant. This study aimed to determine the total phenolic compounds, antioxidant capacity, antibacterial and antifungal activities, cytotoxicity evaluation, and characterize the phytochemical compounds present in the extract. The results indicated that extraction by agitation at 30 ºC obtained the highest yield of total phenolic compounds (48.23 mg GAE g-1), antioxidant capacity (40.34 mg TEAC g-1), and IC50 (2.60 mg mL-1). The extracts at 30 and 60 ºC inhibited all microorganisms tested, and the temperature of 30 ºC acted as a bactericide and fungicide at low concentrations. Ten phytochemical compounds were found, mainly being antioxidants and antimicrobials. The cytotoxicity assays showed that Inga marginata seeds do not present cellular cytotoxicity up to the concentration of 250 µg mL-1, maintaining cell viability above 90%.

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Ingacamerounol, A New Flavonol and Other Chemical Constituents from Leaves and Stem Bark of Inga edulis Mart.

Cited by 8 publications

References 19 publications

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Phenolic compounds, antimicrobial activity, cytotoxicity, and identification of phytochemicals present in Inga marginata Willd seeds

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