Ingadosides A-C, acacic acid-type saponins from Inga sapindoides with potent inhibitory activity against downy mildew

Heng, Ming Yuan; Thuerig, Barbara; Danton, Ombeline; Ramseyer, Justine; Gupta, Mahabir P.; Tamm, Lucius; Hamburger, Matthias; Potterat, Olivier

doi:10.1016/j.phytochem.2022.113183

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Several extracts have shown near total suppression of downy mildew alone or in conjunction with additional phytocompounds. A 96% ethanolic extract from the leaves of Inga sapindoides offers greenhouse grapevine plantlets defense against downy mildew that is comparable to copper treatments [158]. At 0.5 mg/mL, this extract provided 96% or 97% reduction in downy mildew compared to a 100% reduction with the copper treatment [158].…”

Section: Plant Extractsmentioning

confidence: 97%

“…A 96% ethanolic extract from the leaves of Inga sapindoides offers greenhouse grapevine plantlets defense against downy mildew that is comparable to copper treatments [158]. At 0.5 mg/mL, this extract provided 96% or 97% reduction in downy mildew compared to a 100% reduction with the copper treatment [158]. A phytocomplex, derived from Salvia officinalis and containing rosmarinic acid (10.12% w/w), applied to grapevine leaf discs at 5 g/L that were then inoculated with P. viticola, inhibited sporulation by 95% compared to the control and was significantly better than the 77% inhibition by rosmarinic acid alone [159].…”

Section: Plant Extractsmentioning

confidence: 99%

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Traditional and Emerging Approaches for Disease Management of Plasmopara viticola, Causal Agent of Downy Mildew of Grape

Clippinger,

Dobry,

Laffan

et al. 2024

Agriculture

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The oomycete Plasmopara viticola, which causes downy mildew, is currently one of the most destructive pathogens affecting grape production. Although native to the eastern United States, P. viticola was introduced into Europe in the mid-to-late 1800s and is now found in virtually every grape-growing region of the world. Since its discovery, much effort has been made to understand the life cycle and infection process of the pathogen to develop more effective management practices. Widespread application of fungicides, especially those which have only one mode of action, has led to an increased occurrence of resistance to these treatments. Thus, with increased fungicide resistance and rising environmental concerns surrounding their use, traditional chemical management practices have begun to fall out of favor. Newer approaches, from targeted breeding utilizing quantitative trait loci to biological control agents, are continually being investigated and adapted to limit the damage caused by downy mildew. This review summarizes the current knowledge of the pathogen and methods of its control and explores potential avenues for future research focused on hypovirulence and biological control agents.

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Section: Plant Extractsmentioning

confidence: 97%

Section: Plant Extractsmentioning

confidence: 99%

Traditional and Emerging Approaches for Disease Management of Plasmopara viticola, Causal Agent of Downy Mildew of Grape

Clippinger,

Dobry,

Laffan

et al. 2024

Agriculture

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“…Other studies highlighted disease severity reduction above 90% on leaf discs with plant extracts and essential oils obtained from different species such as Artemisia absinthium, Equisetum arvense, Frangula alnus, Glycyrrhiza glabra, Melaleuca alternifolia, Picea abies, Quillaia saponaria, Rheum palmatum, Salix alba and Yucca schidigera [14][15][16][17][18][19][20]. Moreover, Inga sapindoides, Juncus effusus, Larix sibirica, Oreganum vulgare, Pinus sylvestris, Solidago canadensis and Verbesina lanata plant extracts have been successfully tested in greenhouse-cultivated seedlings, with plant protection efficacy above 80% [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Suppressive Activity of Glechoma hederacea Extracts against the Phytopathogenic Oomycete Plasmopara viticola, and First Screening of the Active Metabolites

Zorrilla,

Giovannini,

Nadalini

et al. 2023

Agriculture

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Plasmopara viticola is a destructive oomycete that affects grapevines, causing significant economic losses worldwide. This study highlights how the plant Glechoma hederacea might be at the basis for the development of biofungicides to control P. viticola. The aqueous extract obtained from G. hederacea aerial parts showed strong inhibition activity against P. viticola, comparable to that of copper hydroxide. The bioguided purification of the extract by chromatographic techniques led to the isolation of six pure metabolites, identified as the aromatic compounds carvacrol, caffeic acid and methyl caffeate, the flavonoids cirsimaritin and apigenin and the polyphenolic acid rosmarinic acid by spectroscopic methods. This is the first report about the isolation of methyl caffeate and cirsimaritin from G. hederacea. Caffeic acid and methyl caffeate showed the highest disease severity reduction, while carvacrol, cirsimaritin and apigenin also showed moderate activity against P. viticola. The inhibitory activity of the aqueous extract could suggest synergetic or additive action of caffeic acid and methyl caffeate together with other compounds contained in the extract. This study provides insights into the potential of G. hederacea as an allelopathic tool for developing control methods against P. viticola, revealing the combined action of different metabolites involved in the mechanism of action of the active compounds.

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Biological control of Plasmopara viticola: where are we now?

Nadalini,

Puopolo

2024

Biocontrol Agents for Improved Agriculture

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Ingadosides A-C, acacic acid-type saponins from Inga sapindoides with potent inhibitory activity against downy mildew

Cited by 3 publications

References 26 publications

Traditional and Emerging Approaches for Disease Management of Plasmopara viticola, Causal Agent of Downy Mildew of Grape

Traditional and Emerging Approaches for Disease Management of Plasmopara viticola, Causal Agent of Downy Mildew of Grape

Suppressive Activity of Glechoma hederacea Extracts against the Phytopathogenic Oomycete Plasmopara viticola, and First Screening of the Active Metabolites

Biological control of Plasmopara viticola: where are we now?

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