InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Abstract

Therapies that accelerate the healing of burn injuries, improving the quality of life of the patient and reducing the cost of treatment are important. This study evaluated the effects of InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis leaves on burn wound healing in rats. Seventy-two rats were divided randomly into four groups: control untreated (C), treated with InGaP 670-nm laser with power density of 0.41 W/cm(2) and energy density of 4.93 J/cm(2) (L), treated with S. chilensis extract (S) and treated with S. chilensis extract and laser (LS). Second-degree burns were produced on the back of the animals with metal plate. Wound samples were collected on days 7, 14 and 21 of treatment for structural analysis, morphometry and Western blotting to quantify the expression of transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). The results showed that InGaP laser irradiation at 670 nm alone and combined with extract of S. chilensis promoted significant tissue repair responses in this experimental model, increasing the number of fibroblasts, collagen fibres and newly formed blood vessels throughout the experimental period and decreasing the number of granulocytes in burn wounds of second degree in all treated groups. Exclusive treatment of burn wounds with the hydroalcoholic extract of S. chilensis provided similar quantitative results to those seen in the untreated group throughout the experimental period. Therefore, it was observed in the L and LS groups different responses in the expression of TGF-β1 and VEGF. The application of 670-nm laser alone or combined with the extract of S. chilensis promoted favourable responses in tissue repair of second-degree burns in this experimental model.

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

“…Although several studies on laser photobiomodulation ensured the improvement of scar repair, specially secondintention wound healing, some studies compared the clinical efficacy of laser application with topical herbal medicine (Catarino et al, 2015;Jácomo et al, 2015).…”

Casearia sylvestris Improved Cutaneous Burn Repair in Diabetic Rats

“…The use of medicinal plants as a treatment for wound healing has long been used [10,11]. There are many studies about the effect of herbal medicines in the treatment of burn [12][13][14]. Plants represent important sources of bioactive substances that can be used in therapeutic proposals due to the great diversity of metabolites produced, as well as serving as models for synthetic D DAVID PUBLISHING chemicals [15].…”

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“…Second-degree burns are characterized by an injury to the epidermis and part or deeper layers of the dermis [2]. Therapies that improve their healing are of a great importance, especially for being minimally invasive, of low cost and best performance related to the speed and quality of healing [3,4].…”

“…Facing complications observed in burns and ulcers, several therapeutic approaches are used to achieve an acceptable outcome with a treatment, including the use of medicinal herbs and electromagnetic stimulation [4,12,13]. Herbal medicines have shown great potential in the treatment of burns [14] with great antimicrobial and anti-inflammatory potential [4,[15][16][17].…”

“…Herbal medicines have shown great potential in the treatment of burns [14] with great antimicrobial and anti-inflammatory potential [4,[15][16][17]. Aloe vera has a healing action that occurs because it maintains the moisture of the wound, stimulates cell migration and proliferation, maturation of collagen and reduces the inflammatory process.…”