Ingasaponin, a complex triterpenoid saponin with immunological adjuvant activity from Inga laurina

Cruz, Maria de Fátima Simão Jucá; Pereira, Gabriela Moysés; Ribeiro, Marcela Gonçalves; Silva, Ari Miranda da; Tinoco, Luzineide W.; Silva, Bernadete Pereira da; Parente, José Paz

doi:10.1016/j.carres.2015.11.008

Cited by 12 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,11 Such benefits have been related to the high antioxidant activity due to anthocyanins, flavonoids, 12 phenolic acids, catechin, 11 trypsin inhibitors, 13,14 and saponins. 15 I. edulis Martius is the most widespread Inga species. 12,16 However, its fruits are not widely cultivated and explored, which implies that there are only a small number of studies available in the literature on I. edulis .…”

Section: Introductionmentioning

confidence: 99%

Active Compounds From Inga edulis Martius Seeds Against Multiple Myeloma

Ferro

Cretton

Polese

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

Multiple myeloma is an incurable hematological cancer with an average survival time of only 5 to 10 years due to the high rate of relapse and resistance. Although the introduction of novel classes of drugs has improved the standard of care, new strategies are urgently needed. Plants are primary sources of bioactive natural compounds for cancer treatment. This study aimed at evaluating the in vitro inhibitory activity of the Inga edulis seed extract against multiple myeloma cells, as well as the compounds isolated from this extract. The ethanolic extract of the seeds of I. edulis inhibited 85% of RPMI 8226 cell proliferation at 20 µg/mL. Then, the extract was subjected to a bioassay-guided fractionation to afford 3 saponins known as concinnoside D (1), julibroside A1 (2), and julibroside A3 (3). The isolated saponins exhibited antiproliferative activity with IC50 values in the low µM range for compounds 2 and 3. Compound 1 was considered inactive (IC50 > 20 µM). Therefore, the seeds of I. edulis could be considered as a source of active compounds against multiple myeloma.

show abstract

Section: Introductionmentioning

confidence: 99%

Active Compounds From Inga edulis Martius Seeds Against Multiple Myeloma

Ferro

Cretton

Polese

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…Substituents in the basic nucleus, such as hydroxyls, carboxyls and methoxyls, differentiate the compounds identified in this group. Carbohydrates are generally linked as an ether bond at C-3 or at the carboxyl at C-FIGURE 3: Example of a monoterpenic portion present in triterpenoid saponins [6] .…”

Section: Introductionmentioning

confidence: 99%

Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

Cruz

Pereira

2022

Rev Fitos

Self Cite

View full text Add to dashboard Cite

Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.

show abstract

“…Entre las sustancias químicas caracterizadas en estas especies vegetales se encuentra la ingasaponina aislada de I. laurina con actividad auxiliar inmunológica [4], así como de I. marginata. En general se detectaron saponinas, taninos, fitoesteroles, triterpenos, estigmasterol, alcanos de cadena larga y de los gajos se aislaron lupeol, lupenona, fricolelina y antraquinonas como fisciona y emodin y de las hojas emodin, quercetina, fisciona y ácido kaurénico [5], y un amino ácido no proteico, trans-4-metoxipipecólico de las hojas de I. paterno [6].…”

Section: Introductionunclassified

Extracción, Separación, E Identificación Del Carotenoide Y Xantófilo Neoxantina Por HPLC-MS De La Especie Alimentica Inga Ingoides (Rich) Willd, Pacay, Colectada en Coroico, Bolivia

P¹,

Chávez²,

Bascopé

et al. 2020

Rev. Bol. Quim.

View full text Add to dashboard Cite

En el presente trabajo se describe el aislamiento y caracterización de neoxantina obtenida en la parte aérea de la especie vegetal Inga ingoides colectada en la localidad de Coroico del Departamento de La Paz, Bolivia. La planta fue sometida a procesos de extracción y de cromatografía en columna sobre silica gel, con fase móvil de éter de petróleo/acetato de etilo de gradiente polar creciente. La fracción mayoritaria de cromatografía de coloración rojiza obtenida, fue sometida a cromatografía líquida de alta resolución acoplada a espectrometría de masas HPLC_MS determinándose la presencia de neoxantina.

show abstract

Ingasaponin, a complex triterpenoid saponin with immunological adjuvant activity from Inga laurina

Cited by 12 publications

References 29 publications

Active Compounds From Inga edulis Martius Seeds Against Multiple Myeloma

Active Compounds From Inga edulis Martius Seeds Against Multiple Myeloma

Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

Extracción, Separación, E Identificación Del Carotenoide Y Xantófilo Neoxantina Por HPLC-MS De La Especie Alimentica Inga Ingoides (Rich) Willd, Pacay, Colectada en Coroico, Bolivia

Contact Info

Product

Resources

About