Ingenol Mebutate Gel after Cryotherapy of Actinic Keratosis: When can I Start the Topical Treatment?

Abstract

Actinic keratosis (AK) is a common dermatological disorder on sun-exposed skin. Its premalignant condition is widely known; therefore both treatment and protection from sunlight are needed to prevent malignant transformation. Field and lesion-targeted therapies can be combined to search a synergistic effect. Here we report our experience with cryotherapy and ingenolmebutate used sequentially, without rest interval between both treatments.