Ingestion of transient receptor potential channel agonists attenuates exercise‐induced muscle cramps

Craighead, Daniel H.; Shank, Sean W.; Gottschall, Jinger S.; Passe, Dennis H.; Murray, Bob; Alexander, Lacy M.; Kenney, W. Larry

doi:10.1002/mus.25611

Cited by 16 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Muscle cramps of athletes upon isometric strain might resemble a similar situation. TRPA1 and transient receptor potential vanilloid 1 (TRPV1) agonists prevent such cramps, supporting our findings (Craighead et al, 2017). Lee and colleagues reported on deteriorated motor performance of TRPA1 KO mice (Lee et al, 2017).…”

Section: Discussionsupporting

confidence: 89%

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

et al. 2019

View full text Add to dashboard Cite

Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented. The present study aims to investigate TRPA1-mediated effects of sulfide donor GYY4137 in K/BxN serum-transfer arthritis, a rodent model of rheumatoid arthritis. TRPA1 and somatostatin sst4 receptor wild-type (WT) and knockout mice underwent K/BxN serum transfer and were treated daily with GYY4137. Functional and biochemical signs of inflammation were recorded, together with histological characterization. These included detection of hind paw mechanical hyperalgesia by dynamic plantar esthesiometry, hind paw volume by plethysmometry, and upside-down hanging time to failure. Hind paw erythema, edema, and passive movement range of tibiotarsal joints were scored. Somatostatin release from sensory nerve endings of TRPA1 wild-type and knockout mice in response to polysulfide was detected by radioimmunoassay. Polysulfide formation from GYY4137 was uncovered by cold cyanolysis. GYY4137 aggravated mechanical hyperalgesia in TRPA1 knockout mice but ameliorated it in wild-type ones. Arthritis score was lowered by GYY4137 in TRPA1 wild-type animals. Increased myeloperoxidase activity, plasma extravasation, and subcutaneous MIP-2 levels of hind paws were detected in TRPA1 knockout mice upon GYY4137 treatment. Genetic lack of sst4 receptors did not alter mechanical hyperalgesia, edema formation, hanging performance, arthritis score, plasma extravasation, or myeloperoxidase activity. TRPA1 WT animals exhibited smaller cartilage destruction upon GYY4137 administration. Sodium polysulfide caused TRPA1-dependent somatostatin release from murine nerve endings. Sulfide released from GYY4137 is readily converted into polysulfide by hypochlorite. Polysulfide potently activates human TRPA1 receptors expressed in Chinese hamster ovary (CHO) cells. According to our data, the protective effect of GYY4137 is mediated by TRPA1, while detrimental actions are independent of the ion channel in the K/BxN serum-transfer arthritis model in mice. At acidic pH in inflamed tissue sulfide is released from GYY4137 and reacts with neutrophil-derived hypochlorite. Resulting polysulfide might be responsible for TRPA1-mediated antinociceptive and anti-inflammatory as well as TRPA1-independent pro-inflammatory effects.

show abstract

Section: Discussionsupporting

confidence: 89%

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The "oral sensing" benefits of CHO have been shown to be robust and repeatable when undertaken throughout an event, offering new performance nutrition strategies and a different range of targeted sports (76). Although this science is still in its infancy, evidence shows benefits of oral sensing from other tastants (e.g., fluid and caffeine), and effects have been reported for menthol (perception of cooling), quinine [activation of the autonomic nervous system and/or corticomotor excitability for brief events (79)], and capsaicin, acetic acid, cinnamaldehyde, and other plant chemicals that are known transient receptor potential channel activators and may prevent exercise-associated muscle cramps (80).…”

Section: Solving the Fuel Crisismentioning

confidence: 99%

Swifter, higher, stronger: What’s on the menu?

Burke

Hawley

2018

Science

View full text Add to dashboard Cite

The exploits of elite athletes delight, frustrate, and confound us as they strive to reach their physiological, psychological, and biomechanical limits. We dissect nutritional approaches to optimal performance, showcasing the contribution of modern sports science to gold medals and world titles. Despite an enduring belief in a single, superior “athletic diet,” diversity in sports nutrition practices among successful athletes arises from the specificity of the metabolic demands of different sports and the periodization of training and competition goals. Pragmatic implementation of nutrition strategies in real-world scenarios and the prioritization of important strategies when nutrition themes are in conflict add to this variation. Lastly, differences in athlete practices both promote and reflect areas of controversy and disagreement among sports nutrition experts.

show abstract

“…TRP channels are a group of ion channels located in the mouth, esophagus and stomach that regulate the flow of ions, i.e., charged particles like sodium and potassium, across cell membranes. Recent evidence suggests that oral ingestion of TRP channel agonists like cinnamon, peppers, or mustard may attenuate the intensity and/or duration of muscle cramps, presumably by dampening alpha motor neuron excitability [74,75]. These studies produced muscle cramps by electrical stimulation.…”

Section: Other Etiological Factors In Eamcmentioning

confidence: 99%

Exercise Associated Muscle Cramps - A Current Perspective

Qiu¹,

Kang²

2017

Arch Sports Med

View full text Add to dashboard Cite

Exercise-associated muscle cramps (EAMC) are a common condition experienced by recreational and competitive athletes and often require medical attention during or immediately after sports events. Despite the high prevalence of this condition, the etiology of EAMC remains poorly understood, and there is a lack of high levels of evidence to guide the management of this condition. The previous claim as to how EAMC come about is being challenged by more recent evidence suggesting a distinctive mechanism. EAMC has been long attributed to an excessive sweat sodium loss together with dehydration. However, growing evidence suggests that EAMC occurs with sustained and repetitive muscle contraction that results in fatigue. The purpose of this article is to examine the existing scientific evidence in support of various views on the etiology of EAMC and to highlight the most current understanding of this complex condition. Various strategies adopted to treat and prevent EAMC also are discussed even though most of them remain anecdotal and have yet to be substantiated by research experimentation.

show abstract

Ingestion of transient receptor potential channel agonists attenuates exercise‐induced muscle cramps

Cited by 16 publications

References 33 publications

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Swifter, higher, stronger: What’s on the menu?

Exercise Associated Muscle Cramps - A Current Perspective

Contact Info

Product

Resources

About