Ingestive and locomotor behaviours induced by pharmacological manipulation of &lt;Alpha&gt;-adrenoceptors into the median raphe nucleus

Levone, Brunno Rocha; Cella, Elisa Caroline; Kochenborger, Larissa; Silva, Eduardo Simão da; Taschetto, Ana Paula Dambros; Mansur, Samira Schultz; Terenzi, Mariana Graciela; Faria, Moacir Serralvo; Paschoalini, Marta Aparecida

doi:10.1016/j.neuropharm.2014.09.016

Cited by 4 publications

(2 citation statements)

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“…(Goldberg and Gonzalez, 1976;Harris et al, 1996;Norman and Tsibulsky, 2006;Willuhn et al, 2014;Wise et al, 1995). Propranolol also reduced pellet intake on the FR5 schedule in PP and CP rats with negligible effects on motivation, which is consistent with another study ((Harris et al, 1996), but see the study by Goldberg and Gonzalez (1976)), suggesting greater satiety/anorexia-potentially via enhanced NE overflow and subsequent α1-AR activation in (hypothalamic) feeding circuits (Levone et al, 2015;Tuross and Patrick, 1986;Wellman et al, 2002). In this regard, the greater propranolol-induced hypophagia in CP rats may reflect more pronounced alterations in NE neurotransmission.…”

Section: Discussionsupporting

confidence: 76%

“…β-AR antagonists also reduce cocaine responding, but potentiate cocaine-induced DA in the NAc (Harris et al, 1996). Activation of α1-or β-AR in several brain regions underlies stimulant-induced hypophagia (Leibowitz, 1975;Levone et al, 2015;Wellman et al, 2002;Wellman, 2000). Therefore, we treated animals with the α1-AR antagonist (terazosin) and non-selective β-AR antagonist (propranolol) to examine effects on cocaine preferences.…”

Section: Introductionmentioning

confidence: 99%

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The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats

Perry

Westenbroek

Jagannathan

et al. 2015

Neuropsychopharmacol

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Cocaine dependence is characterized by compulsive drug taking and reduced involvement in social, occupational, or recreational activities. Unraveling the diverse mechanisms contributing to the loss-of-interest in these 'non-drug' pursuits is essential for understanding the neurobiology of addiction and could provide additional targets for treating addiction. The study objectives were to examine changes in cocaine-induced dopamine (DA) overflow in the nucleus accumbens (NAc) over the course of self-administration and determine the roles of α1-and β-adrenergic receptors (AR) in the loss-of-interest in food rewards following the development of an addicted phenotype in male and female rats. Subjects were given access to cocaine and palatable food pellets in a choice self-administration paradigm to identify 'addicted' cocaine-preferring (CP) individuals and resistant pellet-preferring (PP) individuals based on their patterns of self-administration over 7 weeks. Cocaine-induced DA overflow in the NAc was examined with microdialysis early and late during self-administration (weeks 2 and 7). Subjects were treated in counter-balanced order with propranolol (β-AR antagonist), terazosin (α1-AR antagonist), or vehicle for an additional 3 weeks of self-administration. CP rats displayed increased motivation for cocaine and attenuated motivation for pellets following the development of cocaine preferences. In females, the estrous cycle affected pellet, but not cocaine, self-administration. CP rats displayed attenuated cocaine-induced DA overflow in the NAc. Propranolol enhanced cocaine reinforcement and reduced pellet intake, whereas terazosin enhanced motivation for pellets and reversed preferences in a subset of CP rats. The implications of these results for the treatment of addiction are discussed.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats

Perry

Westenbroek

Jagannathan

et al. 2015

Neuropsychopharmacol

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Injections of the of the α1-adrenoceptor antagonist prazosin into the median raphe nucleus increase food intake and Fos expression in orexin neurons of free-feeding rats

Silva

Flores

Ribas

et al. 2017

Behavioural Brain Research

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Evaluation of food intake and Fos expression in serotonergic neurons of raphe nuclei after intracerebroventricular injection of adrenaline in free-feeding rats

et al. 2018

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Previous studies indicate that the modification of adrenergic neurotransmission in median raphe nucleus (MRN) enhances or removes an inhibitory influence on food intake, possibly serotonergic, due to a presence of serotonin-producing neurons in that nucleus. Therefore, the aim of this study is evaluated whether the activity of neurons in the MRN and dorsal raphe nucleus (DRN) are affected by intracerebroventricular injection of adrenaline (AD) in free-feeding rats. Male Wistar rats with guide cannulae chronically implanted in the lateral ventricle were injected with AD followed by evaluation of ingestive behavioral parameters. Behavior was monitored and the amount of food ingested was assessed. The highest dose (20 nmol) of AD was the most effective dose in increasing food intake. Subsequently, AD 20 nmol was injected to study neuronal activity indicated by the presence of Fos protein and its co-localization with serotonergic neurons in the MRN and DRN of naive rats with or without access to food during the recording of behavior. The administration of AD 20 nmol increased Fos expression and double labeling with serotonergic neurons in the DRN in rats with access to food, but not in animals without access. No statistically significant changes in Fos expression were observed in the MRN in any of the experimental conditions tested. These results suggest that DRN serotonergic and non-serotonergic neurons are activated by post-prandial signals. In contrast, the absence of Fos expression in the MRN suggests that this nucleus does not participate in the circuit involved in the control of post-prandial satiety.

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Ingestive and locomotor behaviours induced by pharmacological manipulation of <Alpha>-adrenoceptors into the median raphe nucleus

Cited by 4 publications

References 54 publications

The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats

The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats

Injections of the of the α1-adrenoceptor antagonist prazosin into the median raphe nucleus increase food intake and Fos expression in orexin neurons of free-feeding rats

Evaluation of food intake and Fos expression in serotonergic neurons of raphe nuclei after intracerebroventricular injection of adrenaline in free-feeding rats

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