Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Abstract

Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis.

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

“…However, complications, such as blood pressure problems and infections, have been reported following some of these treatments [36]. Therefore, plant extracts with joint protective effects and few side effects have been prioritized in the search for an alternative treatment for OA [37][38][39]. One candidate is MF, a traditional herbal product with anti-inflammatory, antioxidant, and abdominal pain-reducing effects [21,26]; however, its effect on OA remains unknown.…”

Evaluating the Anti-Osteoarthritis Potential of Standardized Boswellia serrata Gum Resin Extract in Alleviating Knee Joint Pathology and Inflammation in Osteoarthritis-Induced Models

“…Boswellia serrata gum resin, an oleo-gum resin derived from the Boswellia serrata tree indigenous to the Indian highlands, has historically been used as a remedy for chronic inflammatory diseases and arthritis [ 12 ]. It includes six types of boswellic acids, notably, keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA), which exhibit pronounced antioxidant and anti-inflammatory properties [ 13 , 14 , 15 ]. Previous research has substantiated the anti-osteoarthritis efficacy of FJH-UBS, a derivative of Boswellia serrata gum resin enriched in KBA and AKBA, in interleukin (IL)-1β-stimulated human SW1353 chondrocytes [ 16 ] and osteoarthritis-induced animal models of osteoarthritis [ 17 ].…”

The impact of ascorbic acid (E 300) on digestion of different nutrients using In Vitro digestion model

“…Ascorbic acid is very beneficial for diabetic patients through competing with blood glucose, reducing glycosylated hemoglobin concentration, eliminating free radicals, inhibiting intracellular accumulation of sorbitol and reducing low-density lipoproteins at high doses administration to patients [5]. There are many studies focused on the effectiveness and importance of ascorbic acid in improving hospitalized COVID-19 patients as early therapy taken intravenously [6], as being a powerful antioxidant , vitamin C enhance immune system competence and immune cells functions and migration [7], being a water-soluble antioxidant, plays a vital role in protecting the host cells against the detrimental effects of reactive oxygen species (ROS). All those mentioned properties made it a corner stone as Supportive Therapy in the Treatment of COVID-19 [8].…”