Inguinal hernia in patients with Ewing sarcoma: A clue to etiology

Cope, Judith U.; Tsokos, Maria; Helman, Lee J.; Gridley, Gloria; Tucker, Margaret A.

doi:10.1002/(sici)1096-911x(200003)34:3<195::aid-mpo6>3.0.co;2-b

Cited by 21 publications

(22 citation statements)

References 14 publications

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“…Several variables previously associated with childhood cancer or Ewing's sarcoma were evaluated for potential confounding, including childhood diagnosis of hernia, parental smoking status during pregnancy, birth weight, maternal consumption of alcohol, caffeine, and medications during pregnancy, parental age at birth, maternal exposure to X-rays during pregnancy and childhood exposure to X-rays. 9,10,[13][14][15][16][17][18][19] Evidence of confounding (Ͼ10% change in the OR or statistical significance at p Ͻ 0.1) was observed when childhood diagnosis of hernia and the smoking status of the mother during the pregnancy were included in models. All models were adjusted for these, as well as probable exposure of fathers to organic dusts during usual occupation after pregnancy, because this exposure was found to be a significant risk factor.…”

Section: Methodsmentioning

confidence: 99%

“…9 -19 Recently, several studies, including the current study, have reported a link between incidence of ES and elevated rates of inguinal hernia. 9,[12][13][14]20 We hypothesized that the hernias were due to a disruption in embryological development, possibly as a result of an in utero parental exposure to an environmental insult, which could also have led to ES. To evaluate the developmental disruption hypothesis, we used data from Winn et al 13 and developed new occupational exposure assessments to examine parental occupational exposures during the pregnancies of children who developed ES and controls.…”

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confidence: 99%

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Parental occupational exposures and Ewing's sarcoma

Moore

Gold

Stewart

et al. 2004

Intl Journal of Cancer

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A case-control study of Ewing's sarcoma (ES) was conducted to search for occupational exposures associated with ES. The study consisted of 196 cases and 196 random-digit controls matched on geographical region, gender, ethnic origin and birth date. A questionnaire was administered to mothers of participants to obtain information on medical conditions, medications, and parental occupations during and after the index pregnancy. An occupational exposure expert coded jobs and industries for possible and probable exposure to selected occupational hazards. Risk of ES was increased with probable parental exposure to wood dusts during their usual occupation post pregnancy (odds ration [OR] ‫؍‬ 3.2; 95% confidence interval [CI] ‫؍‬ 1.1-9.2). Other exposures, including a priori suspected risk factors such as exposure to pesticides and farm animals, were not significantly associated with ES. A history of household pesticide extermination was associated with ES among boys aged 15 or younger (OR ‫؍‬ 3.0; 95% CI ‫؍‬ 1.1-8.1), but not among girls or older boys. Our results suggest that earlier reports of associations of ES with parental farm employment may have been describing risks associated with organic dusts encountered when working on a farm, rather than agricultural exposures or other farming related exposures.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Parental occupational exposures and Ewing's sarcoma

Moore

Gold

Stewart

et al. 2004

Intl Journal of Cancer

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“…The varying magnitude of this hernia effect may reflect design differences, mostly related to selection of cases 3,4,7 and controls 3,4,7 or possible confounding by age 3,4,7 or other factors. Winn et al 4 compared 208 cases ascertained from a number of U.S. institutions to 2 sets of controls, a sibling and a geographically matched control.…”

Section: Discussionmentioning

confidence: 99%

“…The other associations reported here await replication and refinement in future studies that include more narrowly defined cases [possibly using characteristics such as histopathology, biologic markers or cases that have the cytogenetic translocation t (11;22)(q24; q11. [2][3][4][5][6][7][8][9][10][11][12]] and have a greater number of newly diagnosed cases. Although aetiology of ESFT remains obscure, overall there is now strong evidence for an association between ESFT and inguinal hernias 3,4,7,11 and between ESFT and farm-related exposures that include parental occupation in farming.…”

Section: Discussionmentioning

confidence: 99%

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A national case‐control study of Ewing's sarcoma family of tumours in Australia

Valery

McWhirter

Sleigh

et al. 2003

Intl Journal of Cancer

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Limited population-based epidemiologic information is available on Ewing's sarcoma family of tumours (ESFT), a rare group of neoplasms. Several associations have been noted on a few studies but results were not consistent, except for exposure to farming among cases and their parents. Here we present the non-farm findings of a nationwide casecontrol study of ESFT in children and young adults in Australia. The analysis included 106 persons with confirmed ESFT and 344 population-based controls selected randomly via telephone. Information was collected by interview (84% face to face). We found a strong and significant association of ESFT with hernias, in particular hernia repaired in hospital (OR ‫؍‬ 5.6, 95% CI 1.3-6.4). Among other factors, there was a near doubling of risk for males, and male cases had their pubertal signs earlier (started shaving earlier) than male controls. There was also an increased risk of ESFT at higher levels of self-assessed exercise, but no other factor really stood out. For pregnancy-related factors, there was a tripling of risk for glandular fever, a doubling of risk for urinary tract infection and a near doubling of risk for X-rays during or just before pregnancy, but these estimates were not significant. In addition, there was a large number of inverse associations with medical conditions (specifically bone disorders), case exposure to medications, vaccinations and X-rays, with ultrasound during the pregnancy having the most certain effects. We conclude that, although the aetiology of ESFT remains obscure, overall there is strong evidence of an association with inguinal hernia; this can now be added to the farmassociated risk reported by others and us. The other associations reported here await replication and refinement in future studies.

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Morphologies and mechanical properties of polylactide blends with medium chain length poly(3‐hydroxyalkanoate) and chemically modified poly(3‐hydroxyalkanoate)

Takagi

Yasuda

Yamaoka

et al. 2004

J of Applied Polymer Sci

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ABSTRACT:Blends of bacterial poly(3-hydoroxyalkanoate) (PHA) with a medium-length side chain and polylactide (PLA), and blends of the chemically modified PHA (ePHA) with PLA, were prepared. The morphologies, some physical properties, and thermal behavior of the blends based on PLA were investigated by electron microscopies, testing machines, and a differential scanning calorimeter, respectively. A blend of uncrystallized rubbery second components, PHA and ePHA, produced an increase in the impact toughness of the PLA blends in contrast to a decrease in the tensile strength value. PHA, especially, with an inserted epoxy group side chain was more effective in improving the morphology and the physical properties than PHA. The ePHA particles existed in the PLA domain as a dispersed phase having a size of 0.1-1 m. The results of the biodegradation test demonstrated that the PLA blends still maintained their biodegradability and were more accessible to hydrolysis and microbial attack, resulting in a greater weight loss than the pure PLA.

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Inguinal hernia in patients with Ewing sarcoma: A clue to etiology

Cited by 21 publications

References 14 publications

Parental occupational exposures and Ewing's sarcoma

Parental occupational exposures and Ewing's sarcoma

A national case‐control study of Ewing's sarcoma family of tumours in Australia

Morphologies and mechanical properties of polylactide blends with medium chain length poly(3‐hydroxyalkanoate) and chemically modified poly(3‐hydroxyalkanoate)

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