Peritoneal dialysis (PD) is a form of kidney replacement therapy that offers flexibility and autonomy to patients with end stage kidney disease. It is associated with lower costs compared to hemodialysis in many countries. However, it can be associated with unexpected interruptions to, or discontinuation of therapy. Timely diagnosis and resolution are required to minimize preventable modality change to hemodialysis. This review covers mechanical complications, including leaks, PD hydrothorax, hernias, dialysate flow problems, PD-related pain, and changes in respiratory mechanics. Most mechanical complications occur early, either as a result of PD catheter insertion or the introduction of dialysate and consequent increased intraabdominal pressure. Late mechanical complications can also occur, and may require different treatment.