Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties

Ma, Cheng; Wu, Mingjun; Ye, Weifen; Huang, Zhengwei; Ma, Xiangyu; Wang, Wenhao; Huang, Ying; Pan, Xin; Wu, Chuanbin

doi:10.1007/s13346-020-00849-7

Cited by 56 publications

(35 citation statements)

References 46 publications

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“…toxicology, pharmacology & pharmacy, science & technology: other topics, chemistry, environmental sciences & ecology, materials science, engineering, public environmental & occupational health, physics, and biochemistry & molecular biology. These research areas could be roughly categorized into three groups: (I) pharmacological and toxicological aspects, about the in vivo processes of inhalable nano-systems (Liu et al 2020); (II) material aspects, about the fabrication of inhalable nanosystems (Ma et al 2021); (III) public environmental aspects, about the impact of nano-systems in the environment on human health (Creutzenberg et al 2012). There were 1668, 784, and 569 documents associated with pharmacological and toxicological, material, and public environmental aspects, respectively.…”

Section: Bibliometric Profilesmentioning

confidence: 99%

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Huang

Wang

et al. 2022

J Nanopart Res

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were showcased. The bibliometric analysis of 3362 documents of interest indicated that most of the relevant source titles were in the fields of toxicology, pharmacy, and materials science. The three research hotspots were the biological process of inhalable nano-systems in vivo, the manufacture of inhalable nano-systems, and the impact of nano-systems on human health in the environment. Toxicity and safety have always been the keywords. The USA was the major contributing country, and international collaboration and co-authorship were common phenomena. The general situation and development trend of literature of inhalable nano-systems were summarized. It was anticipated that bibliometrics analysis could provide new ideas for the future research of inhalable nano-systems.

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Section: Bibliometric Profilesmentioning

confidence: 99%

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Huang

Wang

et al. 2022

J Nanopart Res

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“…Coated SLNs displayed sustained rifampicin release in addition to higher phagocytic uptake compared to the free drug; however, mannosylation reduced the reparability of the formulation as its adsorbed moisture resulted in powder aggregation (Maretti et al, 2017). In a more recent paper, Ma et al (2020) applied mannose for surface modification of SLNs loaded with isoniazid prodrug, isonicotinic acid octylidene-hydrazide. Mannose-coated SLNs showed pH-responsiveness due to the protonation of the imine group of isonicotinic acid octylidene-hydrazide in an acidic medium.…”

Section: Saccharide-coated Nanoparticlesmentioning

confidence: 99%

Surface modification of nano‐drug delivery systems for enhancing antibiotic delivery and activity

Osman

Devnarain

Omolo

et al. 2021

WIREs Nanomed Nanobiotechnol

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Rampant antimicrobial resistance calls for innovative strategies to effectively control bacterial infections, enhance antibacterial efficacy, minimize side effects, and protect existing antibiotics in the market. Therefore, to enhance the delivery of antibiotics and increase their bioavailability and accumulation at the site of infection, the surfaces of nano-drug delivery systems have been diversely modified. This strategy applies various covalent and non-covalent techniques to introduce specific coating materials that have been found to be effective against various sensitive and resistant microorganisms. In this review, we discuss the techniques of surface modification of nanocarriers loaded with antibacterial agents. Furthermore, saccharides, polymers, peptides, antibiotics, enzymes and cell membranes coatings that have been used for surface functionalization of nano-drug delivery systems are described, emphasizing current approaches for enhancing delivery, bioavailability, and efficacy of surfacemodified antibacterial nanocarriers at infection sites. This article offers a critical overview of the potential of surface-modified antibacterial nanocarriers to overcome the limitations of conventional antibiotics in the treatment of bacterial infections.

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“…Different works demonstrating the ability of antibiotic-loaded SLNs to increase bacteria death inside macrophages have been published [ 55 , 56 , 99 , 100 ]. Hosseini and coworkers obtained doxycycline-encapsulated SLNs composed of palm oil, lecithin and Tween-80 to improve drug efficiency against Brucella melitensis , an infection that to date has no efficient treatment because the survival of the bacteria inside the macrophages makes them safe from the immune system and disrupts drug delivery mechanism.…”

Section: Solid Lipid Nanoparticles Can Reduce Antibiotic Resistance Mechanismsmentioning

confidence: 99%

“…For this reason, mannose-receptors are interesting targets to stimulate cell uptake of antibiotic-loaded SLNs in alveolar macrophages to increase antibiotic concentration inside cells. Different groups have developed SLNs formulations modifying nanoparticle surfaces with mannose to take advantage of this mechanism [ 55 , 100 ]. In recent work, Ma and coworkers modified SLNs surface with mannose to activate macrophage uptake by mannose receptors, and this specific endocytic pathway improved nanoparticle cell uptake.…”

Section: Solid Lipid Nanoparticles Can Reduce Antibiotic Resistance Mechanismsmentioning

confidence: 99%

“…Additionally, to improve drug retention and efficiency, the antibiotic release was pH-sensitive, obtaining a targeted drug release inside the macrophage endosomes. Combining both strategies exhibited a noteworthy increase in the intracellular antibiotic efficiency in the in vitro latent tuberculosis infection model and excellent antibiotic efficacy in the in vivo antibiotic tests compared to the free drug solution [ 100 ]. SLNs surface modification with mannose residues also has demonstrated the potential to promote selective uptake by lung tissues, obtaining a site-specific delivery and reducing side-effects [ 103 ].…”

Section: Solid Lipid Nanoparticles Can Reduce Antibiotic Resistance Mechanismsmentioning

confidence: 99%

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Incorporation of Antibiotics into Solid Lipid Nanoparticles: A Promising Approach to Reduce Antibiotic Resistance Emergence

2021

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Antimicrobial resistance is one of the biggest threats to global health as current antibiotics are becoming useless against resistant infectious pathogens. Consequently, new antimicrobial strategies are urgently required. Drug delivery systems represent a potential solution to improve current antibiotic properties and reverse resistance mechanisms. Among different drug delivery systems, solid lipid nanoparticles represent a highly interesting option as they offer many advantages for nontoxic targeted drug delivery. Several publications have demonstrated the capacity of SLNs to significantly improve antibiotic characteristics increasing treatment efficiency. In this review article, antibiotic-loaded solid lipid nanoparticle-related works are analyzed to summarize all information associated with applying these new formulations to tackle the antibiotic resistance problem. The main antimicrobial resistance mechanisms and relevant solid lipid nanoparticle characteristics are presented to later discuss the potential of these nanoparticles to improve current antibiotic treatment characteristics and overcome antimicrobial resistance mechanisms. Moreover, solid lipid nanoparticles also offer new possibilities for other antimicrobial agents that cannot be administrated as free drugs. The advantages and disadvantages of these new formulations are also discussed in this review. Finally, given the progress of the studies carried out to date, future directions are discussed.

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Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties

Cited by 56 publications

References 46 publications

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Surface modification of nano‐drug delivery systems for enhancing antibiotic delivery and activity

Incorporation of Antibiotics into Solid Lipid Nanoparticles: A Promising Approach to Reduce Antibiotic Resistance Emergence

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