Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

Luedders, Brent A.; Mikuls, Ted R.; Thiele, Geoffrey M.; Poole, Jill; England, Bryant R.

doi:10.1016/j.rdc.2022.06.002

Cited by 3 publications

(1 citation statement)

References 81 publications

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“…Previous studies have shown that the use of dinitrophenol to induce mitochondrial dysfunction of colon epithelial cells will lead to intestinal barrier dysfunction, indicating that mitochondrial dysfunction will damage the integrity of intestinal epithelial cells; At the same time, MitoTEMPO, an antioxidant targeting mitochondria, can inhibit the above barrier defects, which indicates that the stability of mitochondrial function is very important for maintaining intestinal barrier function (Wang et al, 2014). Disruption of the intestinal mucosa barrier will cause some chronic diseases such as RA, diabetes, inflammatory bowel disease and other autoimmune diseases and celiac disease, as well as bacterial displacement and endotoxemia (Li & Chen, 2013; Lu et al, 2021; Luedders et al, 2022). Therefore, improving the intestinal mucosa barrier may be expected to become a new strategy to treat or prevent RA.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

Li,

Jia,

Cui

et al. 2023

Clinical Anatomy

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Rheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical barrier, immune barrier, and microflora barrier. It is a dynamic system that contributes to the stability of the intestinal environment by regulating the absorption of relevant substances from the lumen into the circulation, while limiting the passage of harmful substances. This article summarizes the connection between the intestinal mucosa barrier and RA, and proposes the role of relevant Chinese medicines on RA from the point of improving barriers, to provide new perspectives on the pathogenesis and therapeutic strategies of RA.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

Li,

Jia,

Cui

et al. 2023

Clinical Anatomy

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Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study

Parks,

Leyzarovich,

Hamra

et al. 2024

Sci Rep

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Pesticides and farming have been associated with increased rheumatoid arthritis (RA) risk, but the role of specific pesticides remains unknown. We examined RA risk among licensed pesticide applicators (97% white male farmers), from North Carolina and Iowa, in the Agricultural Health Study, in relation to lifetime use of 45 pesticides reported at enrollment (1993–1997, updated 1999–2003). In 22,642 applicators ages ≥ 67 years with ≥ 24 months Fee for Service Medicare data (1999–2016), we identified 161 (0.7%) incident cases with ≥ 2 RA claims (including ≥ 1 by a rheumatologist), ≥ 30 days apart, after ≥ 12 months without RA claims. Relative risks (RR) and 95% Confidence Intervals (CI) were calculated using log-binomial models adjusted for age, state, education, smoking, and correlated pesticides. Risk was elevated (RR > 1.5 or lower CI > 0.95) for use of nine pesticides: four insecticides [malathion (RR = 1.77;95%CI = 1.14–2.73), phorate (1.40;0.96–2.04), carbaryl (1.65;1.10–2.46), carbofuran (1.41;0.99–2.01)], four herbicides [alachlor (RR = 1.40;95%CI 0.99–1.98), metolachlor (1.57;1.11–2.23), S-Ethyl dipropylthiocarbamate (1.57;1.00-2.44), metribuzin (1.45; 1.01, 2.08)], and one fungicide [benomyl (1.56;0.99–2.44)]. Exposure-response was seen for greater intensity-weighted lifetime days use of malathion and carbofuran (p-trends = 0.03 and 0.05). Some specific pesticides, including several currently approved and commonly used in agricultural, public health, or residential settings may increase RA risk among older adults.

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The Multimorbidity Web in rheumatoid arthritis

England

2023

Rheumatology

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Multimorbidity, the presence of multiple chronic conditions, is highly prevalent in people with RA. An essential characteristic of multimorbidity is the interrelatedness of the different conditions that may develop in a multimorbid person. Recent studies have begun to identify and describe the Multimorbidity Web by elucidating unique multimorbidity patterns in people with RA. The primary multimorbidity patterns in this web are cardiopulmonary, cardiometabolic, and mental health and chronic pain multimorbidity. Once caught in the Multimorbidity Web, the consequences can be devastating, with reduced quality of life, physical function, survival, and treatment responses observed in multimorbid RA persons. The development of effective management and preventive approaches for multimorbidity in people with RA is in its infancy. Determining how best to assess, intervene, and prevent multimorbidity in RA is crucial to optimize long-term outcomes in people with RA.

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Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis

Cited by 3 publications

References 81 publications

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study

The Multimorbidity Web in rheumatoid arthritis

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