Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model

Salles, Évila Lopes; Naeini, Sahar Emami; Khodadadi, Hesam; Bhandari, B. N.; Rezaee, Sholeh; Threlkeld, Edie; Rogers, Hannah M.; Costigliola, Vincenzo; Terry, Alvin V.; Hess, David C.; Deb, Sumitra; Yeudall, W. Andrew; Yu, Jack C.; Wang, Lei P.; Baban, Babak

doi:10.1007/s13577-023-00869-8

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…Further, excessive neuroinflammatory responses could affect the homeostasis negatively through metabolic irregularities and accelerated cellular senescence (29-32). Immoderate and exaggerated cellular senescence could drive the pathologic processes leading to vascular and neurodegenerative diseases (33)(34)(35). Therefore, exploring novel alternative and effective immunomodulatory strategies to sustain the homeostasis is crucial in the battle against drug abuse and addiction.…”

Section: Introductionmentioning

confidence: 99%

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

Bhandari,

Shimaoka Chagas,

Naeini

et al. 2024

Preprint

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Introduction: Fentanyl and non-pharmaceutical fentanyl use have been the leading causes of opioid-induced death worldwide. Being 50 times stronger than heroin and 100 times stronger than morphine, fentanyl is a potent opioid with overdoses causing over 250,000 deaths since 2018 in the US alone. The treatment of fentanyl addiction is a complex process and a clinical challenge. There is a dire need to find other innovative and alternative modalities in the fight against fentanyl crisis. Increasing evidence suggests a correlation between neuroinflammation and symptoms of drug abuse, opening up the possibility of immunoregulatory agents as therapy for fentanyl addiction as well as a other opioid-induced addiction. Cannabidiol (CBD) is a non-opioid, relatively safe, non-psychoactive phyto-cannabinoid produced by cannabis plants. Importantly, recent reports have documented benefits of CBD in the treatment and management of complications related to opioid withdrawal. We investigated if inhaled CBD could reverse the fentanyl addiction and whether the CBD treatment could ameliorate the addiction symptoms by regulating neuroinflammatory signals and re-establishing the homeostasis in CNS. Method: We used a fentanyl-induced conditioned place preference (CPP) model in mouse to test whether inhaled CBD could reverse the fentanyl addiction and ameliorate the adversarial symptoms. By employing a combination of flow cytometry as well as behavioral tests, we further assessed the impact of fentanyl addiction on cells and neuroinflammatory signals in CNS and we measured the effects of CBD in the treatment of addiction symptoms and inflammatory signals. Results: Our findings suggest that CBD inhalation could be used effectively in the treatment of fentanyl addiction. CBD mitigated the excessive fentanyl-induced neuroinflammatory responses and decreased cellular stress and senescence. Conclusion: inhaled CBD could alleviate the fentanyl addiction and regulate neuroinflammatory responses. This novel approach is non-invasive, accessible, effective, and warrants further, translational and research.

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Section: Introductionmentioning

confidence: 99%

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

Bhandari,

Shimaoka Chagas,

Naeini

et al. 2024

Preprint

Self Cite

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“…Notably, it exhibits potential in suppressing the expression of Id-1 in metastatic breast cancer cells (McAllister et al, 2011), safeguarding against brain damage, enhancing neuron and astrocyte protection (Lafuente et al, 2011), regulating inflammatory responses in asthma (Vuolo et al, 2015), and potentially benefiting Alzheimer's disease management (Martin-Moreno et al, 2011). Moreover, CBD inhalants have exhibited inhibitory effects on lung cancer growth by downregulating CD44 and impeding angiogenesis in nude mice (Salles et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Unlocking the Socioeconomic Advantages of Cannabis Sativa L. Legalization in African Countries: An In-Depth Review

Antonio,

Gana,

Adukeye

et al. 2023

GJAR

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Cannabis sativa L., an annual, dioecious, short-day plant from the Cannabaceae family, presents versatile applications encompassing cannabinoids and terpenes for medicinal or recreational utilization, as well as oil production for culinary, cosmetic, and animal feed purposes. Additionally,the plant's resilient fiber can be processed as paper, biodegradable plastics, textiles, and as construction materials (i.e., hempcrete). On a global scale, the cannabis market is projected to attain a value of $272 billion by 2028. Despite its considerable potential, some countries, including African nations, uphold prohibition due to entrenched stigma, curtailing Africa's potential involvement in the cannabis industry. Unlike regions such as the United States and Europe, where outdoor cannabis cultivation occurs once annually, Africa's climatic conditions and fertile soils allow for up to three growth cycles each year, positioning the continent as a potential frontrunner in global cannabis production. This prospect holds the potential to significantly enhance Africa's socioeconomic development by fostering job creation, addressing youth unemployment, increasing its GPD, and spurring infrastructure development. However, these inherent advantages remain underutilized due to an enduring lack of cannabis education programs that can counteract social stigma. We recommend African countries to contemplate emulating the 2018 US Farm Bill, which allows the cultivation of cannabis cultivars with diminished levels of Δ9-THC (up to 0.3%), commonly known as hemp. Hemp possesses diverse applications, encompassing medicinal uses involving CBD, THCV, CBG and other non-psychotropic cannabinoids, alongside fiber, feed, and oil production. This strategic step could yield substantial job prospects and entrepreneurial ventures, potentially generating an annual revenue surpassing $7.0 billion from cannabis and hemp flower sales exclusively.

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Cannabidiol effects in stem cells: A systematic review

Mesas,

Moreno,

Doello

et al. 2024

BioFactors

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Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo‐ and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles analyzed, 38 were selected according to the inclusion and exclusion criteria. A total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD differentiation effect and 56% on its protective activity. On the other hand, 11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%), lung cancer (27%), and breast cancer (only one article). Our results showed that CBD exerted a differentiating and protective effect on SCCs. In addition, this molecule demonstrated an antiproliferative effect on some CSCs, although most of the analyses were performed in vitro. Therefore, although in vivo studies should be necessary to justify its clinical use, CBD and its receptors could be a specific target to act on both SSCs and CSCs.

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Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model

Cited by 8 publications

References 15 publications

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

Cannabidiol reverses fentanyl-induced addiction and modulates neuroinflammation

Unlocking the Socioeconomic Advantages of Cannabis Sativa L. Legalization in African Countries: An In-Depth Review

Cannabidiol effects in stem cells: A systematic review

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