Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

Clifford, Rachel L.; Jones, Meaghan J.; MacIsaac, Julia L.; McEwen, Lisa M.; Goodman, Sarah J.; Mostafavi, Sara; Kobor, Michæl S.; Carlsten, Chris

doi:10.1016/j.jaci.2016.03.046

Cited by 120 publications

(99 citation statements)

References 41 publications

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“…A single exposure to allergen, diesel exhaust, or both was sufficient to induce significant methylation changes at 7 CpG sites within 48 hours. However, significant changes in more than 500 CpGs were observed if the same individual was exposed to allergen and diesel exhaust 4 weeks apart [48]. In individuals who had been previously exposed to diesel exhaust, 70 CpGs showed changes ≥10% and were significantly associated with allergen exposure after correcting for multiple testing.…”

Section: Impact Of Asthma-associated Exposures On the Methylome: In Vmentioning

confidence: 98%

The Neonatal Methylome as a Gatekeeper in the Trajectory to Childhood Asthma

DeVries

Vercelli

2017

Epigenomics

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Asthma is a heterogeneous group of conditions that typically begin in early life and result in recurrent, reversible bronchial obstruction. The role played by epigenetic mechanisms in the pathogenesis of childhood asthma is understood only in part. Here we discuss asthma epigenetics within a developmental perspective based on our recent demonstration that the epigenetic trajectory to childhood asthma begins at birth. We next discuss how this trajectory may be affected by prenatal environmental exposures. Finally, we examine in vitro studies that model the impact of asthma-associated exposures on the epigenome. All of these studies specifically surveyed human DNA methylation and involved a genome-wide component. In combination, their results broaden our understanding of asthma pathogenesis and the role the methylome plays in this process.

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Section: Impact Of Asthma-associated Exposures On the Methylome: In Vmentioning

confidence: 98%

The Neonatal Methylome as a Gatekeeper in the Trajectory to Childhood Asthma

DeVries

Vercelli

2017

Epigenomics

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“…The same authors showed an interaction with glutathione- S -transferase theta-1 and DE in the activation of cytotoxic T cells in lung lavage, and in the development of airflow limitation (with glutathione- S -transferase theta-1-null plus DE exposure) (100). An epithelial epigenetic effect has been shown: acute exposure to DE and/or allergen alters expression of microRNA and genes, with effects on inflammatory markers associated with asthma (101, 102). There are methylation changes in airway epithelium after acute DE exposure, and exposure–exposure epigenetic interactions caused by DE with allergen exposure.…”

Section: Methodsmentioning

confidence: 99%

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Tarlo¹,

Malo²,

Blay³

et al. 2017

Annals ATS

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The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects. A summary of the presentations and discussion is provided in this proceedings document. Increased knowledge has been gained in each topic over the past few years, but there remain aspects of controversy and uncertainty requiring further research.

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“…For example, gene–environment interactions have been demonstrated with changes in microRNA [3] and bronchial epithelial DNA methylation, after exposures to diesel exhaust [104]. For individuals with atopy-prone or immune modulated genotypes, environmental exposures play a role in the onset of an allergic disorder [105], including exposures to aeroallergens [2,106].…”

Section: Reviewmentioning

confidence: 99%

“…Particulate matter smaller than 2.5 μm (PM 2.5 ) reaches deeply in the lungs and acts as an adjuvant that increases production of IgE [3,151,152]. Furthermore, exposure to diesel exhaust is known to impact DNA methylation and impaired regulatory T-cell functions, two mechanisms relevant for the immune response [104]. Changes in FEV1 following allergen exposure have also been modified by controlled diesel exhaust exposure and GST genotype in a gene–environment interaction manner [152].…”

Section: Reviewmentioning

confidence: 99%

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

Sierra-Heredia

North

Brook

et al. 2018

IJERPH

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Aeroallergens occur naturally in the environment and are widely dispersed across Canada, yet their public health implications are not well-understood. This review intends to provide a scientific and public health-oriented perspective on aeroallergens in Canada: their distribution, health impacts, and new developments including the effects of climate change and the potential role of aeroallergens in the development of allergies and asthma. The review also describes anthropogenic effects on plant distribution and diversity, and how aeroallergens interact with other environmental elements, such as air pollution and weather events. Increased understanding of the relationships between aeroallergens and health will enhance our ability to provide accurate information, improve preventive measures and provide timely treatments for affected populations.

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Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

Cited by 120 publications

References 41 publications

The Neonatal Methylome as a Gatekeeper in the Trajectory to Childhood Asthma

The Neonatal Methylome as a Gatekeeper in the Trajectory to Childhood Asthma

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

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