Inhalation of Sodium Pyruvate to Reduce the Symptoms and Severity of Respiratory Diseases Including COVID-19, Long COVID, and Pulmonary Fibrosis

Abstract

COVID19 is a disease caused by the novel SARS-CoV-2 virus [1]. In the last 1.5 years since the spread of this virus began a world-wide pandemic, hundreds of millions of people have become infected and millions have died [2]. Although the advent of any novel pathogen is likely to result in widespread infection and mortality, SARS-CoV-2 induces a particularly severe and rapid form of pneumonia in some patients concomitant with an overall cytokine storm but diminished interferon responses [3]. Although case severity varies by sex, age and comorbidities, some of the most severe comorbidities include high blood pressure, diabetes and interstitial lung disease [4].Interstitial lung disease encompasses a large group of chronic lung disorders associated with excessive tissue remodeling, scarring, fibrosis, decreased FEV1 values, decreased SaO2 and decreased Nitric Oxide (NO) associated with nasal inflammation that causes congestion, coughing and sleep disorders [5,6]. Researchers have demonstrated that pulmonary fibrosis increases risk and susceptibility to COVID-19 infection [7]. Acute exacerbations of idiopathic pulmonary fibrosis (IPF) are known as serious events, which can reach a mortality rate of 50% when viral infections play a role [8]. This isn't surprising considering pulmonary fibrosis and severe cases of COVID-19 share a few

Sodium Pyruvate Nasal Spray Reduces the Severity of Nasal Inflammation and Congestion in Patients with Allergic Rhinitis

“…We previously showed in Pulmonary Fibrosis patients that treatment with N115 nasal spray for 21 days significantly improved nasal inflammation. 15 Here, we demonstrate that sodium pyruvate can also decrease inflammation in the nasal tissues in five clinical trials with AR patients. Importantly, in study 3, sodium pyruvate treatment significantly improved nasal inflammation with a single treatment within 1 hour.…”

“…These findings could also have an impact on the treatment of COPD, pulmonary fibrosis, COVID-19, and long COVID, since patients with these diseases often suffer from nasal inflammation. 13 , 15 , 16…”

“…This can play a major role in prevention and intervention of inflammatory responses. 15 , 16 Clinically, sodium pyruvate has a good safety profile and has been given to patients for a variety of disorders ranging from Friedreich's ataxia 17 to open heart operations. 18 It has been administered via several routes, including intravenous, 18 topical administration, 19 dietary supplementation, 20 and intranasally.…”

“… 18 It has been administered via several routes, including intravenous, 18 topical administration, 19 dietary supplementation, 20 and intranasally. 15 , 16 The purpose of the five studies presented here was to test the therapeutic value of sodium pyruvate to improve nasal inflammation in patients with AR.…”