Inhalation of talc baby powder by hamsters

Wehner, Alfred P.; Zwicker, Gary M.; Cannon, W.C.

doi:10.1016/s0015-6264(77)80317-9

Cited by 44 publications

(29 citation statements)

References 14 publications

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“…It was noted that the degree of fibrosis seen with talc was significantly less than the confluent fibrosis seen in asbestosis or the fibrosis seen in silicosis. Wehner et al (1975) studied the effect of inhalation of a commercially available cosmetic talc powder in Syrian golden hamsters. The talc dust consisted of 97 % mineral talc in platy form free of detectable asbestos and silica.…”

Section: Studies In Animalsmentioning

confidence: 99%

The biology of talc.

Hildick‐Smith¹

1976

Occupational and Environmental Medicine

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-229. The biology of talc. Data are presented on the effects on health of talc dusts from exposure in industry and use of talc-containing health products. The mineralogy of talc and the composition of cosmetic and industrial grade talc dusts are described. Studies in animals are reviewed, and epidemiological data are considered in relation to exposures that occur during industrial and consumer uses of talc dusts. Hamsters exposed to 8 mg/m3 of respirable cosmetic grade talc dust for up to 150 minutes a day for 300 consecutive days showed no difference in incidence or nature of pathological lesions from those observed in a group of untreated animals. A retrospective study of the causes of death of 227 talc mine millers exposed to cosmetic grade talc at the threshold limit value for talc (20 million parts per cubic foot) for an average of 15 8 years showed that the causes of death were no different from those in a control cohort not exposed to talc dust. The available data indicate that talc dust exposure in the modern mining of cosmetic grade talc does not appear to be injurious to health. The significantly lower dust exposure in the normal use of cosmetic grade talc dusts in talc-containing health and cosmetic products confirms that their use is not a hazard to health.Increasing interest in the impact of environmental influences on health has in recent years focused attention on the significance of pollutants and prompted a reappraisal of environmental mineral dusts that have had extensive long-term use, but on which there is a paucity of correlated scientific data by which to

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Section: Studies In Animalsmentioning

confidence: 99%

The biology of talc.

Hildick‐Smith¹

1976

Occupational and Environmental Medicine

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“…The data obtained showed that the exposed animals at natural death showed no difference in incidence of any pathology noted from that observed in the control animals studied (Wehner et al, 1975). These data and those obtained in other animal studies have failed to produce any evidence that cosmetic talc is a carcinogen (Hildick-Smith, 1976a).…”

Section: Letter To the Editormentioning

confidence: 52%

Safety of consumer cosmetic talc products

Hildick‐Smith

1977

Journal of Toxicology and Environmental Health

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“…33,34 Additionally, Syrian golden hamsters showed no mesotheliomas after exposure to Vermont talc. 35,36 In the final analysis we are unable to identify any evidence that supports Dr Finkelstein's propositions regarding our statements about spontaneous mesotheliomas, or cases of malignant mesothelioma arising in US women. We identify no evidence for any causative role of cosmetic talc in malignant mesothelioma.…”

Section: In Reply To ''Malignant Mesothelioma and Its Nonasbestos Caumentioning

confidence: 61%