Inhalation unit risk (IUR) of asbestos based on available science

Korchevskiy, Andrey A.; Rasmuson, James O.; Rasmuson, Eric; Strode, Robert D

doi:10.1080/08958378.2020.1829210

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Asbestos mineral type (and the fraction of specific mineral types in the total asbestos consumption) has been repeatedly demonstrated as one of the major predictors of mesothelioma risk [21,22]. In particular, the five amphibole minerals -actinolite, amosite, anthophyllite, crocidolite, and tremolite presented a carcinogenicity definitively higher than chrysotile and, for mesothelioma, the potency factor differences between amphibole and chrysotile is at least of three order of magnitude [23]. Our findings cannot consider this critical issue (according to the absence of adequate data) and this must be considered in their interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings cannot consider this critical issue (according to the absence of adequate data) and this must be considered in their interpretation. In particular, it could be the reason for comparatively higher mesothelioma mortality in the UK, according to the extensive use of the amosite variety of asbestos [23]. In addition to the above limitation, the amount of asbestos consumption is affected by high uncertainty, as well as its yearly variation, in particular for developing countries.…”

Section: Discussionmentioning

confidence: 99%

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Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries

Gariazzo

Gasparrini

Marinaccio

2023

Annals of Global Health

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Background:The causal association between mesothelioma and asbestos exposure is conclusive, and many studies have proved that the trend in asbestos use is a strong predictor of the pattern in mesothelioma cases with an adequate latency time (generally around 30-40 years or more). Recently, a novel approach for predicting malignant pleural mesothelioma, based on asbestos consumption trend and using distributed non-linear models, has been applied. Objectives:The purpose of this study is to analyse trends in asbestos consumption and malignant mesothelioma mortality in the major asbestos-user countries. Furthermore, we applied distributed non-linear models to estimate and compare epidemiological relationships between asbestos consumption and mesothelioma mortality across these countries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries

Gariazzo

Gasparrini

Marinaccio

2023

Annals of Global Health

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Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)]

“Tony” Havics,

Bernstein

2024

Patty's Toxicology

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The term asbestos refers to two very different minerals, serpentine and amphibole, occurring in fibrous form with very different mineralogical properties. Unfortunately, the term “asbestos” has been used loosely when, in fact, it has always been appropriate to discuss them separately. This chapter focuses on the key essential differences which result in very different toxicological and epidemiological responses to the fibers from these two minerals. In particular, it is discussed how a fiber's potency dictates the health risk, how the fiber's mineralogy affects biopersistence in the lung, and how fiber length determines how the lung responds to this characteristic. The differential toxicology is presented, as well as the epidemiology of these fibrous minerals. The regulations in the United Stated are also discussed. It is now convenient to use the term asbestos to describe a subset of elongated mineral particles (EMPs). Although the term has been discussed with potential differing definitions depending on the authors' purpose from 1979 to 2023, a popular working definition for EMPs is any mineral particle with a minimum aspect ratio of 3:1. This chapter will focus on the asbestos subset.

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Theoretical and Practical Aspects of Asbestos Dose–Response Assessment

Korchevskiy,

Rasmuson

2024

Health Risk Assessment for Asbestos and Other Fibrous Minerals

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Inhalation unit risk (IUR) of asbestos based on available science

Cited by 7 publications

References 5 publications

Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries

Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries

Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)]

Theoretical and Practical Aspects of Asbestos Dose–Response Assessment

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