Inhaled anesthetic agents

Stachnik, Joan M

doi:10.2146/ajhp050460

Cited by 77 publications

(44 citation statements)

References 51 publications

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“…The following examples are not exhaustive, but show that sevoflurane may have properties that isoflurane does not, and vice versa. For example, the metabolism of sevoflurane (but not isoflurane) produces inorganic fluoride (Stachnik and Bonk, 2006), a molecule thought to cause nephrotoxicity, although one study on humans found no difference in renal function following prolonged anaesthesia with sevoflurane or isoflurane (Kharasch et al, 2001). Both isoflurane and sevoflurane cause physiological changes in rodents.…”

Section: First Exposurementioning

confidence: 99%

Rat aversion to sevoflurane and isoflurane

Boulanger-Bertolus

Nemeth

Makowska

et al. 2015

Applied Animal Behaviour Science

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Section: First Exposurementioning

confidence: 99%

Rat aversion to sevoflurane and isoflurane

Boulanger-Bertolus

Nemeth

Makowska

et al. 2015

Applied Animal Behaviour Science

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“…However, little is known regarding its comprehensive influence at the genomic and molecular levels, which is not reflected by mortality and morbidity. Sevoflurane is an inhalational anesthetic frequently used in Japan (4). It has low solubility in blood and tissues, thus there is usually a rapid recovery from anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia

Goto

Hori

Ishikawa

et al. 2014

Molecular Medicine Reports

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Abstract. General anesthesia is commonly used in the surgical arena, but little is known regarding its influence at the genomic and molecular levels. MicroRNAs (miRNAs) belong to a new class of non-coding RNA molecules which influence cell biology. In the present study, it was hypothesized that miRNAs alter gene expression levels under general anesthesia. The aim was to compare the miRNA expression profiles in the rat hippocampus in response to anesthesia with representative volatile (sevoflurane) and intravenous (propofol) anesthetics. Wistar Rats were randomly assigned to either a 2.4% sevoflurane, 600 µg/kg/min propofol or control (without anesthetics) group. Total RNA from hippocampal samples which contained miRNA was subjected to quantitative reverse transcriptionpolymerase chain reaction and Taqman Low-Density Arrays (TLDA). A total of 373 miRNAs are associated with rats and the TLDA analysis revealed that 279 expressed miRNAs (74.8%) were expressed in all three groups. Significant differences in the levels of 33 of the 279 expressed miRNAs (11.8%) were observed among the three groups in response to the anesthetic agents, and when compared with the control group, significant differences were found in 26 of the 279 expressed miRNAs (9.3%). Following sevoflurane anesthesia, the levels of four miRNAs were significantly increased and those of 12 were significantly reduced. By contrast, following propofol anesthesia, the levels of 11 miRNAs were significantly reduced but no miRNAs exhibited significantly elevated levels. Fourteen miRNAs were significantly differentially expressed between the two anesthesia groups. In conclusion, sevoflurane and propofol exerted different effects on miRNA expression in the rat hippocampus.

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“…They are also important determinants of numerous pathological states and are the targets of therapeutic, as well as adverse actions, of clinically used pharmacological agents. Volatile general anaesthetics (VAs) induce safe and reversible loss of consciousness, enabling surgical procedures to be carried out (Stachnik, 2006;Bovill, 2008;Franks, 2008). Several membrane ion channels and receptors have been identified as targets of various VAs (Rudolph and Antkowiak, 2004;Hemmings et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Several membrane ion channels and receptors have been identified as targets of various VAs (Rudolph and Antkowiak, 2004;Hemmings et al, 2005). Enhancement of the activity of inhibitory ionotropic receptors (Lobo and Harris, 2005;Zeller et al, 2008), depression of the excitatory ionotropic receptors (Yamakura et al, 2001), potentiation of the 2P-domain K + channels (Patel and Honore, 2001), inhibition of voltage-gated Na + channels (Hemmings, 2009) and of the transient receptor potential (TRP) family member TRPC5 (Bahnasi et al, 2008) probably all contribute to the central clinically relevant anaesthetic effects, whereas the action of the same VAs on other ion channels might, at least in part, be responsible for their numerous adverse effects (Stachnik, 2006;Bovill, 2008). Indeed, activation of TRP member TRPA1 by the 'pungent' VAs (those that are known to excite peripheral nociceptive neurons), isoflurane and desflurane Cornett et al, 2008;Eilers et al, 2010), and sensitization of TRPV1 to its agonists, capsaicin and protons Eilers et al, 2010), might contribute to postoperative pain and inflammation, as well as producing airway irritation.…”

Section: Introductionmentioning

confidence: 99%

Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia

Abeele

Kondratskyi

Dubois

et al. 2013

Journal of Cell Science

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SummaryThe mechanisms by which volatile general anaesthetics (VAs) produce a depression of central nervous system are beginning to be better understood, but little is known about a number of side effects. Here, we show that the cold receptor transient receptor potential melastatin 8 (TRPM8) undergoes a complex modulation by clinical concentrations of VAs in dorsal root ganglion neurons and HEK-293 cells heterologously expressing TRPM8. VAs produced a transient enhancement of TRPM8 through a depolarizing shift of its activation towards physiological membrane potentials, followed by a sustained TRPM8 inhibition. The stimulatory action of VAs engaged molecular determinants distinct from those used by the TRPM8 agonist. Transient TRPM8 activation by VAs could explain side effects such as inhibition of respiratory drive, shivering and the cooling sensation during the beginning of anaesthesia, whereas the second phase of VA action, that associated with sustained TRPM8 inhibition, might be responsible for hypothermia. Consistent with this, both hypothermia and the inhibition of respiratory drive induced by VAs are partially abolished in Trpm8-knockout animals. Thus, we propose TRPM8 as a new clinical target for diminishing common and serious complications of general anaesthesia.

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Inhaled anesthetic agents

Cited by 77 publications

References 51 publications

Rat aversion to sevoflurane and isoflurane

Rat aversion to sevoflurane and isoflurane

Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia

Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia

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