Inhaled Corticosteroid Improves Bronchial Reactivity and Decreases Symptoms in Patients With Mitral Stenosis

Cieslewicz, Grzegorz; Juszczyk, Grzegorz; Foremny, Jerzy; Hamelmann, Eckard; Religa, Z; Zembala, Marian; Gelfand, Erwin W.

doi:10.1378/chest.114.4.1070

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…413 Some patients with MS have increased bronchial reactivity that may improve with inhaled corticosteroids. 414 Salt restriction and intermittent administration of a diuretic are useful if there is evidence of pulmonary vascular congestion. Digitalis does not benefit patients with MS in sinus rhythm unless there is LV or RV dysfunction.…”

Section: Medical Therapy: General (Updated)mentioning

confidence: 99%

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Bonow¹,

Carabello²,

Chatterjee³

et al. 2008

Circulation

916

259

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Section: Medical Therapy: General (Updated)mentioning

confidence: 99%

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Bonow¹,

Carabello²,

Chatterjee³

et al. 2008

Circulation

916

259

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“…These changes lead to a reduction in the cross section of airways and vagotonia. 8 , 9 Moreover, stimulation of sensory-neural endings in lower airways by edema and hyperemia-induced efferent vagal activity may play a role in bronchoconstriction. 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…4 - 7 There are several mechanisms such as interstitial edema and airway mucosal vasodilatation, and also vagotonia which result in decreased airway cross-section and airway hyper-responsiveness in CHF. 8 , 9 Inhaled glucocorticoids can reduce the airway obstruction, so the inflammatory mediators such as arachidonic acid metabolites, platelet-activating factor, TNF, IL1 and IL6 may play a role in bronchial hyper-responsiveness. Glucocorticoids act in several ways such as inhibition of histamine and IgE dependent LTC4 release and reduction of vascular permeability and mucus secretion.…”

Section: Introductionmentioning

confidence: 99%

“…Glucocorticoids act in several ways such as inhibition of histamine and IgE dependent LTC4 release and reduction of vascular permeability and mucus secretion. 9 Increased vagal efferent activity resulting from activation of sensory-neural terminals in the lower airways following edema and hyperemia may lead to bronchospasm. The improvement of forced expiratory volume in one second (FEV1), maximal midexpiratory flow (MMEF) and maximum voluntary ventilation (MVV) following the inhalation of ipratropium bromide confirms the involvement of vagal mechanisms in bronchial obstruction in the patients with CHF.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Prohormone Brain Natriuretic Peptide (NT-proBNP) Level and Severity of Pulmonary Dysfunction in Patients With Chronic Congestive Heart Failure

Nazemiyeh¹,

Sharifi²,

Amiran³

et al. 2015

J Cardiovasc Thorac Res

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Introduction: Congestive heart failure (CHF) is a common disease and its prevalence is increasing in industrialized countries. NT-proBNP measurement is an established diagnostic test for diagnosis of CHF in patients who present to emergency room with acute dyspnea. The primary object of this study was to determine the relationship between levels of brain natriuretic peptide precursor and severity of lung function impairment in patients with chronic CHF. Methods: This cross-sectional and analytical study that performed in Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences on 95 patients with chronic heart failure, and relation between NT-proBNP levels and pulmonary function parameters were examined. Results: Sixty-four patients were male and 31 were female. The average age of male and females was 62.90 ± 11.54 and 61.61 ± 11.98 years, respectively. A significant inverse linear correlation was found between NT-proBNP and FEV1 (P < 0.001, r = -0.367), FVC (P < 0.001, r = -0.444), TLC (P = 0.022, r = -0.238), maximal midexpiratory flow (MMEF) (P = 0.047, r = -0.207) and left ventricular ejection fraction (LVEF) (P < 0.001, r = -0.461). A significant positive linear correlation was found between NT-proBNP and FEV1/FVC (P = 0.013, r = 0.257), RV/TLC (P = 0.003, r=0.303) and 5 Hz Raw (r = 0.231, P = 0.024). Conclusion: This study showed that, both restrictive and obstructive ventilator impairments can occur in chronic CHF and as NT-proBNP increases appropriate to hemodynamic deterioration, pulmonary dysfunction increases.

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“…Inhaled corticosteroids improves bronchial hyperactivity and decreases symptoms in patients with mitral stenosis. [20] As pulmonary venous pressure decreases in patients undergoing mitral valve replacement, lung volumes moderately improve. The most significant change is the decrease of residual volume.…”

Section: Chronic Obstructive Pulmonary Disease and Cardiovascular Dismentioning

confidence: 99%

Effects of chronic obstructive pulmonary disease on morbidity and mortality after mitral valve surgery

Saraçoğlu

Erdinç

Saraçoğlu

et al. 2017

FNG & Bilim Tıp Dergisi

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Chronic obstructive pulmonary disease is characterized by several physiological abnormalities including mucous hypersecretion and ciliary dysfunction, airflow obstruction and hyperinflation, gas exchange abnormalities, pulmonary hypertension and systemic effects. Cardiovascular disease accounts for a significant proportion of deaths. Size of the left atrium, atrial fibrillation, ischemic heart disease and functional capacity are the factors influencing surgical outcomes. The main purpose of medical therapy is to reduce the afterload. Mortality rate is relatively higher in the patients who have pulmonary hypertension, pulmonary edema, renal failure, hepatic failure, acid and severe symptoms.

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Inhaled Corticosteroid Improves Bronchial Reactivity and Decreases Symptoms in Patients With Mitral Stenosis

Cited by 7 publications

References 22 publications

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Relationship Between Prohormone Brain Natriuretic Peptide (NT-proBNP) Level and Severity of Pulmonary Dysfunction in Patients With Chronic Congestive Heart Failure

Effects of chronic obstructive pulmonary disease on morbidity and mortality after mitral valve surgery

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