Inhaled Corticosteroids and Bone Health

Chee, Carolyn; Sellahewa, Luckni; Pappachan, Joseph M

doi:10.2174/1874306401408010085

Cited by 45 publications

(26 citation statements)

References 74 publications

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“…Corticosteroids have detrimental effects on function and survival of osteoblasts and osteocytes, and with the prolongation of osteoclast survival, induce metabolic bone disease 17 . Inhaled corticosteroids are widely accepted for their potent anti-inflammatory effects in the lungs and low systemic activity 18 .…”

Section: Introductionmentioning

confidence: 99%

Treadmill walking exercise modulates bone mineral status and inflammatory cytokines in obese asthmatic patients with long term intake of corticosteroids

El-Kader¹,

Al-Jiffri²,

Ashmawy³

et al. 2016

Afr H. Sci.

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Background: Obesity and asthma are an important public health problem in Saudi Arabia. An increasing body of data supports the hypothesis that obesity is a risk factor for asthma. Asthma appears to be associated with low bone mineral density (BMD) due to long-term use of corticosteroids. Studies recently showed that weight bearing exercise training can increase mineral bone density, reduce weight and improve metabolic control. Objective: The present study aimed to measure the effects of treadmill walking exercises on bone mineral status and inflammatory cytokines in obese asthmatic patients treated with long term intake of corticosteroids. Methods: Eighty obese asthmatic patients of both sexes, their age ranged from 41 to 53 years. Subjects were divided into two equal groups: training group (group A) received aerobic exercise training on treadmill for six months in addition to the medical treatment where, the control group (group B) received only the medical treatment.

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Section: Introductionmentioning

confidence: 99%

Treadmill walking exercise modulates bone mineral status and inflammatory cytokines in obese asthmatic patients with long term intake of corticosteroids

El-Kader¹,

Al-Jiffri²,

Ashmawy³

et al. 2016

Afr H. Sci.

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“…FEV1%Pre and the bone density of lumbar vertebra and the bone density of femoral neck are significantly and positively correlated. However, some research has not found the correlation between the decrease of bone mineral density and the airflow obstruction [25]. In conclusion, there are various factors related to osteoporosis secondary to COPD.…”

Section: Discussionmentioning

confidence: 84%

Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis

Wang¹

2017

AJCEM

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Abstract:Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (P<0.01). The bone density of lumbar vertebra in the low bone mass group and the osteoporosis group decreased when compared with that in the normal bone mass group. The differences were statistically significant (P<0.05, P<0.01). The density of femoral neck in the low bone mass group and the osteoporosis group was significantly lower than that in the normal bone mass group. And there were significant differences (P<0.01). There were significant differences in level of serum MMP-9 among the three groups (P<0.01). Conclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.

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“…Corticoids have damaging effects on the function and survival of osteoblasts and osteocytes, and on the maintenance or prolonging of the lifespan of osteoclasts that are associated with metabolic bone diseases. Osteoporosis caused by corticosteroids is associated with some abnormalities such as fracture of the vertebrae of the spine and femoral neck [26]. Glucocorticoids reduce the process of osteoblastogenesis, increase osteoblasts' cell death, and reduce their ability of bone formation [27].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids

Ghasemalipour

Eizadi

2018

Zahedan J Res Med Sci

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Inhaled Corticosteroids and Bone Health

Cited by 45 publications

References 74 publications

Treadmill walking exercise modulates bone mineral status and inflammatory cytokines in obese asthmatic patients with long term intake of corticosteroids

Treadmill walking exercise modulates bone mineral status and inflammatory cytokines in obese asthmatic patients with long term intake of corticosteroids

Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis

The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids

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