2014
DOI: 10.1002/14651858.cd009878.pub2
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Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth

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Cited by 80 publications
(49 citation statements)
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References 102 publications
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“…In addition, they emphasize the importance of including GR monitoring in future studies and reinforce the recommendation of lower IC doses in children following disease control and during their maintenance treatment. 2 The absence of an association between GR impairment and IC in our study can be explained by the short interval between the two evaluations. Similar results were previously described by Singh et al in preschoolers.…”
Section: Discussioncontrasting
confidence: 54%
See 1 more Smart Citation
“…In addition, they emphasize the importance of including GR monitoring in future studies and reinforce the recommendation of lower IC doses in children following disease control and during their maintenance treatment. 2 The absence of an association between GR impairment and IC in our study can be explained by the short interval between the two evaluations. Similar results were previously described by Singh et al in preschoolers.…”
Section: Discussioncontrasting
confidence: 54%
“…Its use is associated with fewer hospitalizations and care in emergency services, better quality of life and improved lung function. 2 The goal of treatment is control of the disease and remission of exacerbations with the lowest possible doses. 1 Systemic adverse events are described with varying intensity and dependent on the drug, dose and time of use, including: loss of bone mass, inhibition of the hypothalamic pituitary adrenal axis and growth deficit (with no change in growth cartilage).…”
mentioning
confidence: 99%
“…A Cochrane meta-analysis found dose-response effects of ICS on growth. 42 Consequently, children on ICS should have regular monitoring of growth, and health care providers should titrate ICS dosing to the lowest dose that is effective.…”
Section: Figurementioning
confidence: 99%
“…ICS demonstrate a dose-response relationship for both efficacy and safety (as determined by growth velocity); however, most of the benefit is gained with low-to-moderate ICS dose, with minimal benefit in further increasing the dose (8,9). The approach of increasing the dose of ICS from low to moderate is often more practical than adding either LABA or LRTA because the inhaler has already been purchased.…”
Section: Expert Commentarymentioning
confidence: 99%