Inhaled Corticosteroids Should Not Be Prescribed to All Chronic Obstructive Pulmonary Disease Patients

The pharmacoepidemiology of COPD: Recent advances and methodological discussion

“…Secondly, Charlson is never used to control for severity, more for morbidities. Finally, in J. Bourbeau9s study [155], all indicators seem to show that patients diagnosed with COPD and who are receiving ICS have greater severity of disease, not less. I think that empiric evidence suggests that confounding by indication, while we cannot fully explain that away, is unlikely to whittle away the differences.…”