Inhaled D-Limonene minimizes acute lung injury and reduces oxidative stress induced by smoke in rats

Santana, Hericalizandra Santa Rosa; Carvalho, Fernanda Oliveira de; Santos, Danillo Menezes dos; Silva, Eric Aian Pereira da; Silva, Érika Ramos; Saravanan, S.; Heimfarth, Luana; Nunes, Paula Santos; Silva, Ana Mara de Oliveira e; Araújo, Adriano Antunes de Souza; Albuquerque, Ricardo Luiz Cavalcanti de; Santos, Márcio Roberto Viana dos

doi:10.1016/j.phyplu.2022.100308

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…Other compounds identified in this work and their isomers are reported in the literature with antioxidant potential, as is the case of trans-caryophyllene compounds extracted from Carum nigrum seeds ( Singh et al, 2006 ), ß-pinene extracted from Hyssopus officinalis ( Gharakhani-Beni et al, 2022 ), trans -ß -farnesene (isolated compound) ( Lateef et al, 2013 ), limonene ( Santa et al, 2022 ), a compound widely used in the cosmetic and food industry ( Ravichandran et al, 2018 ) and finally, the p -cymene compound also has antioxidant activity reported in the literature ( Balahbib et al, 2021 ). However, the levels obtained strongly depend on the species studied and on the climatic conditions and environments in which the plant was submitted.…”

Section: Discussionmentioning

confidence: 87%

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Henrique Fontoura,

Cristina Perin,

Paula Buratto

et al. 2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 87%

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Henrique Fontoura,

Cristina Perin,

Paula Buratto

et al. 2024

Saudi Pharmaceutical Journal

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“…The results of this study revealed both oral and inhalation use of limonene ameliorates the destructive effect of PDC-induced ALI. However, the inhalation route is preferred for administering limonene to maximize the effectiveness of treatment and minimize the occurrence of adverse reactions [ 46 ]. This route of administration ensures a high concentration of limonene at the targeted location while minimizing its absorption in other organs, in addition to the rapid onset compared to the oral route [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway

Attia,

El-Morshedy,

Nagy

et al. 2024

Metabolites

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Acute Lung Injury (ALI) is a life-threatening syndrome that has been identified as a potential complication of COVID-19. There is a critical need to shed light on the underlying mechanistic pathways and explore novel therapeutic strategies. This study aimed to examine the potential therapeutic effects of Citrus clementine essential oil (CCEO) in treating potassium dichromate (PDC)-induced ALI. The chemical profile of CCEO was created through GC–MS analysis. An in vivo study in rats was conducted to evaluate the effect of CCEO administrated via two different delivery systems (oral/inhalation) in mitigating acute lung injury (ALI) induced by intranasal instillation of PDC. Eight volatile compounds were identified, with monoterpene hydrocarbons accounting for 97.03% of the identified constituents, including 88.84% of D-limonene. CCEO at doses of 100 and 200 mg/kg bw exhibited antioxidant and anti-inflammatory properties. These significant antioxidant properties were revealed through the reduction of malondialdehyde (MDA) and the restoration of reduced glutathione (GSH). In addition, inflammation reduction was observed by decreasing levels of cytokines tumor necrosis factor-α and tumor growth factor-β (TNF-α and TGF-β), along with an increase in phosphatidylinositide-3-kinase (PI3K) and Akt overexpression in lung tissue homogenate, in both oral and inhalation routes, compared to the PDC-induced group. These results were supported by histopathological studies and immunohistochemical assessment of TGF-β levels in lung tissues. These findings revealed that CCEO plays an integral role in relieving ALI induced by intranasal PDC and suggests it as a promising remedy.

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“…Dipentene (limonene) is an antioxidant. Dlimonene, an optical isomer of dipentene (limonene), also exhibits antioxidant and anti-inflammatory properties [52,53]. Antioxidants effectively inhibit oxidative stress, thereby reducing the incidence and development of pathological processes.…”

Section: Discussionmentioning

confidence: 99%

Volatile organic compounds in exhaled breath: a promising approach for accurate differentiation of lung adenocarcinoma and squamous cell carcinoma

Li,

Shi,

Long

et al. 2024

J. Breath Res.

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Lung cancer subtyping, particularly differentiating adenocarcinoma (ADC) from squamous cell carcinoma (SCC), is paramount for clinicians to develop effective treatment strategies. In this study, we aimed: (i) to discover VOC biomarkers for precise diagnosis of ADC and SCC, (ii) to investigated the impact of risk factors on ADC and SCC prediction, and (iii) to explore the metabolic pathways of VOC biomarkers. Exhaled breath samples from patients with ADC (n=149) and SCC (n=94) were analyzed by gas chromatography-mass spectrometry (GC-MS). Both multivariate and univariate statistical analysis method were employed to identify VOC biomarkers. Support vector machine (SVM) prediction models were developed and validated based on these VOC biomarkers. The impact of risk factors on ADC and SCC prediction was investigated. A panel of 13 VOCs was found to differ significantly between ADC and SCC. Utilizing the SVM algorithm, the VOC biomarkers achieved a specificity of 90.48%, a sensitivity of 83.50%, and an AUC value of 0.958 on the training set. On the validation set, these VOC biomarkers attained a predictive power of 85.71% for sensitivity and 73.08% for specificity, along with an AUC value of 0.875. Clinical risk factors exhibit certain predictive power on ADC and SCC prediction. Integrating these risk factors into the prediction model based on VOC biomarkers can enhance its predictive accuracy. This work indicates that exhaled breath holds the potential to precisely detect ADCs and SCCs. Considering clinical risk factors is essential when differentiating between these two subtypes.

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Inhaled D-Limonene minimizes acute lung injury and reduces oxidative stress induced by smoke in rats

Cited by 4 publications

References 59 publications

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil

Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway

Volatile organic compounds in exhaled breath: a promising approach for accurate differentiation of lung adenocarcinoma and squamous cell carcinoma

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