Inhaled essential oil from<i>Chamaecyparis obtuse</i>ameliorates the impairments of cognitive function induced by injection of β-amyloid in rats

Bae, Donghyuck; Seol, Heejin; Yoon, Ho‐Geun; Na, Ju-Ryun; Kyonyeo, OH; Choi, Chul Yung; Lee, Dong‐Wook; Jun, Woojin; Lee, Kwang Youl; Lee, Jeongmin; Hwang, Kwontack; Lee, Yoo‐Hyun; Kim, Sunoh

doi:10.3109/13880209.2011.642886

Cited by 31 publications

(21 citation statements)

References 38 publications

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“…The passive avoidance test was performed as previously described, 36 with minor modifications. The rats were tested for memory retention deficits using a passive avoidance apparatus (Iwoo Scientific Co) consisting of a twocompartment dark/light shuttle box with a guillotine door separating the compartments.…”

Section: Passive Avoidance Testmentioning

confidence: 99%

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

NaJu-ryun

OhDool-Ri

HanSeulHee

et al. 2016

Journal of Medicinal Food

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Our previous results suggest that the Rosa rugosa Thunb. (family Rosaceae) alleviates endurance exercise-induced stress by decreasing oxidative stress levels. This study aimed to screen and identify the physiological antistress effects of an extract of R. rugosa (RO) on sleep deprivation-induced anxiety-like behavior and cognitive tests (in vivo) and tested for hippocampal CORT and monoamine levels (ex vivo), corticosterone (CORT)-induced injury, N-methyl-d-aspartate (NMDA) receptor, and serotonin 6 (5-hydroxytryptamine 6, 5-HT6) receptor activities (in vitro) in search of active principles and underlying mechanisms of action. We confirmed the antistress effects of RO in a sleep-deprived stress model in rat and explored the underlying mechanisms of its action. In conclusion, an R. rugosa extract showed efficacy and potential for use as an antistress therapy to treat sleep deprivation through its antagonism of the 5-HT6 receptor and resulting inhibition of cAMP activity.

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Section: Passive Avoidance Testmentioning

confidence: 99%

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

NaJu-ryun

OhDool-Ri

HanSeulHee

et al. 2016

Journal of Medicinal Food

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“…The following are only some recent examples of essential oils (EO) that have been shown to ameliorate pathological changes in in vivo animal models: Chamaecyparis formosensis Matsum . EO, Zataria multiflora Boiss . EO, Lavandula stoechas L. EO, Coriandrum sativum L. volatile oil or Juniperus communis L. oil .…”

Section: Introductionmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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“…These characteristics were verified by the observed inhibition of the superoxide dismutase activity, following treatment with essential oils [12]. The physiological effects of essential oils have contributed to alleviating the symptoms of various disorders, including allergies, multiple sclerosis, stroke, and cancer [13]. Furthermore, previous investigations have demonstrated that essential oils inhibit the enzymatic activities of cyclooxygenase and lipoxygenase, leading to the reduced production of eicosanoids [14].…”

Section: Introductionmentioning

confidence: 87%

The Effects of Fabric Containing Chamaecyparis obtusa Essential Oil on Atopic Dermatitis-Like Lesions: A Functional Clothing Possibility

Yoo¹,

Kwon²,

Kim³

et al. 2020

Skin Pharmacol Physiol

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Background: Essential oil derived from Chamaecyparis obtusa (EOCO) has been used as an alternative treatment for allergy-related diseases due to its immune-modulating characteristics. Clothing has the longest and most intense contact with human skin, and functional fabrics with intrinsic properties have been increasingly implemented in medical applications. Specially designed fabrics may support atopic dermatitis (AD) treatment. In this study, the effects of fabric containing EOCO on AD were investigated using an NC/Nga mouse model. Methods: The fabric was applied for 6 h per day for 14 days. The therapeutic effects were evaluated according to measurements of skin lesion severity (modified SCORAD score), transepidermal water loss (TEWL), serum IgE and inflammatory cytokine levels, lesion thickness measured after hematoxylin and eosin staining, and immunohistochemical and Western blot analysis for skin epidermal differentiation protein. Results: The EOCO group exhibited significantly reduced modified SCORAD score, TEWL, and serum IgE levels. Among the inflammatory cytokines analyzed, only the mean values of regulated on activation, normal T cell expressed and secreted were observed to be decreased compared with other control groups. The histological analysis of the skin also revealed that the EOCO group expressed reduced epidermal hyperplasia and recovered filaggrin, involucrin, and loricrin expression. Conclusions: It was confirmed that fabric containing EOCO has anti-atopic and antiinflammatory properties. The study data show that fabric containing EOCO can be implemented as an alternative functional clothing for people suffering from AD.

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Inhaled essential oil fromChamaecyparis obtuseameliorates the impairments of cognitive function induced by injection of β-amyloid in rats

Abstract: EOCO suppressed both AD-related neuronal cell apoptosis and AD-related dysfunction of the memory system. Thus, the results of this study support EOCO as a candidate drug for the treatment of AD.

Cited by 31 publications

References 38 publications

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

Natural Monoterpenes: Much More than Only a Scent

The Effects of Fabric Containing Chamaecyparis obtusa Essential Oil on Atopic Dermatitis-Like Lesions: A Functional Clothing Possibility

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Inhaled essential oil fromChamaecyparis obtuseameliorates the impairments of cognitive function induced by injection of β-amyloid in rats

Abstract: EOCO suppressed both AD-related neuronal cell apoptosis and AD-related dysfunction of the memory system. Thus, the results of this study support EOCO as a candidate drug for the treatment of AD.

Cited by 31 publications

References 38 publications

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT6Receptor Antagonist

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT6Receptor Antagonist

Natural Monoterpenes: Much More than Only a Scent

The Effects of Fabric Containing Chamaecyparis obtusa Essential Oil on Atopic Dermatitis-Like Lesions: A Functional Clothing Possibility

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Product

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Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist

Antistress Effects ofRosa rugosaThunb. on Total Sleep Deprivation–Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT₆Receptor Antagonist