Inhaled nitric oxide in cardiology

Hayward, Christopher; Keogh, Anne; Macdonald, Peter S.

doi:10.1517/13543784.10.11.1947

Cited by 9 publications

(3 citation statements)

References 88 publications

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“…Of interest, selective pulmonary vasodilatation by inhaled NO has been demonstrated as a good pharmacological strategy to reduce PH without systemic vasodilatation in humans. [25][26][27] In animals and humans, the PH induced by heparin-protamine is accompanied by systemic hypotension, which may be associated with transient increases in HR and a decrease in the CI. The mechanisms by which these haemodynamic alterations take place are largely unknown, but previous studies suggest that the responses reflect acute right ventricular failure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bay 41‐2272 in the Pulmonary Hypertension Induced by Heparin–protamine Complex in Anaesthetized Dogs

Freitas

Morganti²,

Annichino‐Bizzacchi

et al. 2006

Clin Exp Pharma Physio

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1. BAY 41-2272 is a potent activator of the nitric oxide-independent site of soluble guanylate cyclase and has been recently introduced as a new therapeutic agent to treat chronic pulmonary hypertension (PH) in neonatal sheep. Because the in vivo heparin-protamine interaction may lead to severe PH, the aim of the present study was to evaluate the effects of BAY 41-2272 in the PH induced by heparin-protamine interaction in anaesthetized dogs. 2. Sixteen male dogs (10 mongrel dogs and six Beagles) were anaesthetized and instrumented for acquisition of mean arterial blood pressure (MABP), mean pulmonary arterial pressure (MPAP), heart rate (HR), pulmonary capillary wedge pressure (PCWP), cardiac index (CI) and indices of systemic and pulmonary vascular resistance (ISVR and IPVR, respectively). Plasma cGMP levels and S(p)o(2) were evaluated. 3. Intravenous administration of heparin (500 IU/kg) followed 3 min later by protamine (10 mg/kg) caused marked PH, as evaluated by the increase in MPAP, PCWP and IPVR. This was accompanied by a significant fall in MABP and a transient increase in HR. Infusion of BAY 41-2272 (10 microg/kg per h, starting 10 min before heparin administration) augmented plasma cGMP levels and slightly and significantly increased HR and CI, without affecting the other cardiovascular parameters. The elevation in IPVR, MPAP and PCWP triggered by the heparin-protamine interaction was significantly reduced in animals exposed to BAY 41-2272. 4. In vehicle-treated dogs, the S(p)o(2) values decreased significantly at the peak of the PH and this was significantly attenuated by treatment with BAY 41-2272. In addition, BAY 41-2272 (10 micromol/L) had no effect on the activated partial thromboplastin time of citrated plasma after the addition of heparin-protamine. 5. In conclusion, BAY 41-2272 was effective in reducing canine PH induced in vivo by the heparin-protamine interaction, thus indicating its potential in the treatment of this type of disorder.

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Section: Discussionmentioning

confidence: 99%

Effect of Bay 41‐2272 in the Pulmonary Hypertension Induced by Heparin–protamine Complex in Anaesthetized Dogs

Freitas

Morganti²,

Annichino‐Bizzacchi

et al. 2006

Clin Exp Pharma Physio

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“…17 The efficacy of iNO in the treatment of PH after cardiac surgery for CHD has been demonstrated. [18][19][20] Different from the systemic vasodilation of milrinone, inhaled NO mainly dilates pulmonary blood vessels. 2,3 NO is a powerful pulmonary vasodilator that relaxes pulmonary vascular smooth muscle by activating guanylate cyclase, overcoming the shortcomings of most traditional venous vasodilators, such as systemic hypotension and increased intrapulmonary shunt.…”

Section: Discussionmentioning

confidence: 99%

Effect of postoperative administration of inhaled nitric oxide combined with high‐frequency oscillatory ventilation in infants with acute hypoxemic respiratory failure and pulmonary hypertension after congenital heart surgery: A retrospective cohort study

Huang

Lei

Xie

et al. 2021

Journal of Cardiac Surgery

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Objective: To evaluate the effect of inhaled nitric oxide (iNO) combined with highfrequency oscillatory ventilation (HFOV) in the treatment of infants with acute hypoxemic respiratory failure (AHRF) and pulmonary hypertension (PH) after congenital heart surgery.Methods: A retrospective study was conducted on 63 infants with AHRF and PH after congenital heart surgery in our cardiac intensive care unit (CICU) from January 2020 to March 2021. A total of 24 infants in the A group were treated with HFOV combined with iNO, and 39 infants in the B group were treated with HFOV.Relevant clinical data were collected.Results: Comparing the two groups, the improvement of the oxygenation index, PaO 2 and PaO 2 /FiO 2 was more obvious for patients in the A group than for those in the B group after intervention (p < .05). Reexamination on the third day after the initiation of HFOV treatment indicated that the systolic pulmonary artery pressure in the A group was significantly lower than that in the B group (p < .05). In addition, the duration of mechanical ventilation and the length of CICU stay in the A group were shorter than those in the B group (p < .05). However, complications between the two groups were not statistically significant. No important adverse effects arose.Conclusions: For infants with AHRF and PH after congenital heart surgery, iNO combined with HFOV is superior to HFOV alone to improve oxygenation, decrease pulmonary pressure, and shorten the duration of mechanical ventilation and the length of CICU stay, with no adverse effects.

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“…A vasodilatação pulmonar seletiva com inalação de NO em humanos foi apresentada como uma boa estratégia farmacológica para reduzir a hipertensão pulmonar sem produzir vasodilatação sistêmica Hayward 2001). A inalação de agentes vasodilatadores pode evitar efeitos colaterais sistêmicos e, de fato, estudo recente mostrou que inalação de micropartículas contendo BAY 41 2272, BAY 41 8543 ou BAY 58 2667 produz potente e seletiva vasodilatação pulmonar em cordeiros com hipertensão pulmonar aguda (Evgenov ., 2006)…”

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Efeitos do Bay 41-2272 na hipertensão pulmonar experimental em cães anestesiados

Freitas¹,

Antunes²

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Inhaled nitric oxide in cardiology

Cited by 9 publications

References 88 publications

Effect of Bay 41‐2272 in the Pulmonary Hypertension Induced by Heparin–protamine Complex in Anaesthetized Dogs

Effect of Bay 41‐2272 in the Pulmonary Hypertension Induced by Heparin–protamine Complex in Anaesthetized Dogs

Effect of postoperative administration of inhaled nitric oxide combined with high‐frequency oscillatory ventilation in infants with acute hypoxemic respiratory failure and pulmonary hypertension after congenital heart surgery: A retrospective cohort study

Efeitos do Bay 41-2272 na hipertensão pulmonar experimental em cães anestesiados

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