Inhaled Nitric Oxide to Improve Oxygenation for Safe Critical Care Transport of Adults With Severe Hypoxemia

Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS

“…4,12 We did use inhaled nitric oxide in 57% of the subjects as rescue therapy because it helps to improve oxygenation and was less of a safety risk for the staff. 17 This enabled us to control the oxygenation without driving up the airway pressures. We did not use early high-frequency oscillatory ventilation in our subjects because recent data in ARDS show no benefit.…”

A bench study of inhaled nitric oxide delivery during high frequency percussive ventilation

“…HFPV has been purported to reduce airway pressures and improve outcomes in some case series including during transport and in patients receiving ECMO. 13,14 However, few randomized controlled trials have been performed and neither of these has found a demonstrative benefit compared to conventional ventilation. 15,16 The Bronchotron does provide an option for HFV during transport owing to its compact size.…”

Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive Idiopathic Pulmonary Arterial Hypertension and COVID-19 Infection

“…Inhaled nitric oxide is approved by the USFDA for the treatment of PPHN(5), and used for vasodilatory challenge during right heart catheterization (6). INO is known to provide relief of dyspnea and improve exercise tolerance in adult patients with pulmonary Page 5 of 12 hypertension (PH) and other pulmonary diseases (7), and is widely used a rescue therapy for severely hypoxemic patients with and without PH (8). INO has been associated with varying results in adults with ARDS(9), but more consistent benefit in ARDS associated with a coronavirus pulmonary complication such as SARS (10).…”