Inhaled salbutamol and beclomethasone for preventing broncho-pulmonary dysplasia: a randomised double-blind study

Denjean, A.; Paris-Llado, J; Zupan, V; Debillon, T.; Kieffer, François; Jf, Magny; Desfreres, Luc; Llanas, Brigitte; Guimarães, Hercília; Moriette, G; Voyer, M; Dehan, M; Breart, Gérard

doi:10.1007/s004310050969

Cited by 79 publications

(53 citation statements)

References 24 publications

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“…Timing of BPD assessment differed across studies. One trial reported BPD at 28 days of age,48 four trials reported this outcome at 36 weeks of postmenstrual/postconceptional age37 38 45 46 and three trials used both timing frames for the diagnosis of BPD 39 43 50. Mortality rate was reported at 28 days of age (two trials),39 48 36 weeks of postnatal age (six trials)37–39 45 46 50 and before discharge (one trial) 43…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis

Delara¹,

Chauhan²,

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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Section: Resultsmentioning

confidence: 99%

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis

Delara¹,

Chauhan²,

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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“…5 Inhaled bronchodilators improve airway resistance but do not reduce the incidence of bronchopulmonary dysplasia. 5,14 These disappointing clinical results may reflect either an intrinsic lack of efficacy of these medications or suboptimal delivery. Thus, we suggest that in future neonatal aerosol studies, particularly studies on nasal CPAP, documentation of drug delivery should be included in the study design.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Radio-Labeled Aerosol Delivery Via a Variable-Flow Infant CPAP System

Farney¹,

Kuehne²,

Gibson³

et al. 2013

Respir Care

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BACKGROUND: Nasal CPAP is widely used in neonatal ICUs. Aerosolized medications such as inhaled steroids and ␤ agonists are commonly administered in-line through nasal CPAP, especially to infants with bronchopulmonary dysplasia. We hypothesized that aerosol delivery to the lungs via variable-flow nasal CPAP in an in vitro model would be unreliable, and that the delivery would depend on the position of the aerosol generator within the nasal CPAP circuit. METHODS: We used a system that employed a test lung placed in a plastic jar and subjected to negative pressure. Simulated inspiration effort was measured with a heated-wire anemometer. We used technetium99m-labeled diethylene triamine penta-acetic acid as our aerosol. The nebulizer was placed either close to the humidifier or close to the nasal prongs in the circuit, and patient effort was simulated with a minute ventilation of 0.4 L/min. RESULTS: Relative aerosol delivery to the infant test lung with the nebulizer close to the humidifier was extremely low (0.3 ؎ 0.4%), whereas placing the nebulizer close to the nasal prongs resulted in significantly (P < .001) improved delivery (21 ؎ 11%). Major areas of aerosol deposition with the nebulizer close to the humidifier versus close to the nasal prongs were: nebulizer (10 ؎ 4% vs 33 ؎ 13%, P < .001), exhalation limb (9 ؎ 17% vs 26 ؎ 30%, P ‫؍‬ .23), and generator tubing (21 ؎ 11% vs 19 ؎ 20%, P ‫؍‬ .86). Placing the nebulizer close to the humidifier resulted in 59 ؎ 8% of the aerosol being deposited in the inhalation tubing along the heater wire. CONCLUSIONS: Isotope delivery from an aerosol generator placed near the humidifier on variable-flow nasal CPAP was negligible in this in vitro setup; however, such delivery was significantly improved by locating the aerosol generator closer to the nasal CPAP interface.

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“…13,14 Parece ser aceptable la oxigenoterapia domiciliaria para disminuir la hipertensión pulmonar y la sobrecarga ventricular derecha manteniendo saturaciones ≥94%, es razonable aceptar que la selección y la toma de decisiones debe ser entonces individualizada.…”

Section: Dr Rogelio Sancho Hernándezunclassified

La antigua displasia broncopulmonar organizada en la era de la nueva displasia broncopulmonar

2016

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Inhaled salbutamol and beclomethasone for preventing broncho-pulmonary dysplasia: a randomised double-blind study

Abstract: This randomised prospective trial does not support the use of treatment with inhaled beclomethasone, salbutamol or their combination in the prevention of BPD in premature ventilated neonates.

Cited by 79 publications

References 24 publications

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis

Efficacy and safety of pulmonary application of corticosteroids in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis

In Vitro Evaluation of Radio-Labeled Aerosol Delivery Via a Variable-Flow Infant CPAP System

La antigua displasia broncopulmonar organizada en la era de la nueva displasia broncopulmonar

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