Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement

Li, Yanting; Shi, Teng; Li, Xin; Sun, Haichun; Xia, Xiaowen; Ji, Xiaoya; Zhang, Jianzhong; Liu, Meike; Lin, Yongfeng; Zhang, Rong; Zheng, Yuxin; Tang, Jinglong

doi:10.1016/j.envint.2022.107257

Cited by 66 publications

(20 citation statements)

References 52 publications

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“…Nevertheless, the actual amount of MPs and NPs in the lung could be even higher since the techniques used in that study can only detect MPs larger than 3 μm . In a separate study, it was found that inhalation of MPs originated from tire wear particles may lead to pulmonary fibrosis …”

Section: Introductionmentioning

confidence: 86%

“…16 In a separate study, it was found that inhalation of MPs originated from tire wear particles may lead to pulmonary fibrosis. 24 Once entering the distal lung, the MPs/NPs must first interact with the pulmonary surfactant layer that lines the entire air−water surface of the alveoli as a thin film. The pulmonary surfactant is composed of ∼80 wt % phospholipids, 5−10% neutral lipids, and 5−10% proteins.…”

Section: ■ Introductionmentioning

confidence: 99%

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Microplastics and Nanoplastics Impair the Biophysical Function of Pulmonary Surfactant by Forming Heteroaggregates at the Alveolar–Capillary Interface

Xu,

Goros,

Dong

et al. 2023

Environ. Sci. Technol.

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Section: Introductionmentioning

confidence: 86%

Section: ■ Introductionmentioning

confidence: 99%

Microplastics and Nanoplastics Impair the Biophysical Function of Pulmonary Surfactant by Forming Heteroaggregates at the Alveolar–Capillary Interface

Xu,

Goros,

Dong

et al. 2023

Environ. Sci. Technol.

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“…In humans, maternal exposure to traffic‐related air pollutants, such as nitrogen oxide, PM, and ozone (O 3 ), has been associated with increased inflammatory cytokine levels in newborns, impairing immune system development and postnatal immune functions [24, 23]. Further airborne factors with immunoreactive and inflammatory potential comprise cigarette smoke [25], organic agricultural dust [26], and microplastics [27, 28]. Chemicals, that is, poly‐ and perfluorinated alkyl substances (PFAS), were detected in human blood sera and have been associated with impaired vaccine‐induced antibody responses [29–31].…”

Section: Environmental Factors With Immunoreactive Potentialmentioning

confidence: 99%

Asthma and allergic diseases: Cross talk of immune system and environmental factors

2023

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Air pollution and immune-related diseases including allergy and asthma are constantly on the rise worldwide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for a deeper understanding of disease pathogenesis, progression as well as prevention. Here, we summarize the current knowledge on environmental factors such as microbiome or geographical locations with harmful or protective effects for human health and their different routes of exposure. This review comprises a brief outline regarding the latest findings on the interaction of environmental factors with innate and adaptive regulation of the immune system, exemplarily for one protective and one harmful environmental factor, respectively.

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“…Synthetic fibers and abraded plastic materials are common sources of airborne MPs in both indoor and outdoor settings [50]. It should be noted, however, that the size, density, and hydrophobicity of MP particles will affect their deposition and absorption in the respiratory system [51]. It has been reported that getting rid of accumulated MPs in the lungs can be difficult since MPs have polymeric structures and fibrous morphologies, both of which cause inflammation in the lungs [49].…”

Section: Impact Of Disposable Fm On the Environment And Human Healthmentioning

confidence: 99%

Environmental and Human Health Impact of Disposable Face Masks During the COVID-19 Pandemic: Wood-Feeding Termites as a Model for Plastic Biodegradation

Al-Tohamy

Ali

Zhang

et al. 2022

Appl Biochem Biotechnol

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The ongoing COVID-19 pandemic has resulted in an unprecedented form of plastic pollution: personal protective equipment (PPE). On the eve of the COVID-19 pandemic, there is a tremendous increase in the production of plastic-based PPE. To control the spread of the virus, face masks (FMs) are used as primary PPE. Thus, the production and usage of FM significantly increased as the COVID-19 pandemic was still escalating. The primary raw materials for the manufacturing of FMs are non-biodegradable synthetic polymers derived from petrochemicals. This calls for an urgent need to develop novel strategies for the efficient degradation of plastics. Furthermore, most of these masks contain plastic or other derivatives of plastic. The extensive usage of FM generates millions of tons of plastic waste for the environment in a short span of time. However, their degradation in the environment and consequences are poorly understood. Therefore, the potential impacts of disposable FM on the environment and human health during the COVID-19 pandemic are clarified in the present study. Despite structural and recalcitrance variations, lignocellulose and plastic polymers have physicochemical features, including carbon skeletons with comparable chemical bonds as well as hydrophobic properties in amorphous and crystalline regions. In this review, we argue that there is much to be learned from termites by transferring knowledge from research on lignocellulose degradation by termites to that on plastic waste.

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Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement

Cited by 66 publications

References 52 publications

Microplastics and Nanoplastics Impair the Biophysical Function of Pulmonary Surfactant by Forming Heteroaggregates at the Alveolar–Capillary Interface

Microplastics and Nanoplastics Impair the Biophysical Function of Pulmonary Surfactant by Forming Heteroaggregates at the Alveolar–Capillary Interface

Asthma and allergic diseases: Cross talk of immune system and environmental factors

Environmental and Human Health Impact of Disposable Face Masks During the COVID-19 Pandemic: Wood-Feeding Termites as a Model for Plastic Biodegradation

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