Inhaler Devices in Infants and Children: Challenges and Solutions

In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children

“…Childhood respiratory diseases such as asthma, bronchopulmonary dysplasia, and cystic fibrosis require aerosol therapy as a part of disease management. However, infants pose unique challenges for efficacious aerosol delivery . Some of the challenges that clinicians face during aerosol administration are infant distress, poor cooperation, and facemask leak.…”

Devices for oral and respiratory paediatric medicines: What do healthcare professionals think?

“…There are many reports showing superiority of oral dosing syringes over dosing cups, dosing spoons and household spoons (Grießmann et al, 2007;Sobhani et al, 2008), but syringes are rarely provided with commercialized products (Yin et al, 2010b). Inhalation devices have often been developed for older children and adults and hence, they generally fail to adequately deliver the needed dose to the lung in younger children, who show lower inspiration flow and higher breathing frequency (Everard, 2004;Below et al, 2014).…”

Overcoming Dose Limitations Using the Orbital® Multi-Breath Dry Powder Inhaler

“…routine for higher-dose inhaled formulations is time consuming and thus may result in poor patient compliance in the long term, precluding these products from use outside niche disease indications. (10,11) One of the rate-limiting steps in the realization of highdose inhalation therapy is in the device itself. Best intentions aside, the majority of companies working in this space have modified existing capsule inhaler DPI technology to incorporate engineered drug microparticulate systems, rather than building the device from the ground up, focusing on the required dose.…”