A methodology for achieving the best-fit set of parameters for a MachZehnder interferometer with a semiconductor optical amplifier (MZI-SOA) static model is proposed. A multi-objective genetic algorithm is exploited and the quality of the approach is validated by applying it in an existing sample. Optimisation of performance and determination of operational limits are enabled by the proposed methodology and good agreement was obtained between simulated and practical results.Introduction: Mach-Zehnder interferometers with semiconductor optical amplifiers (MZI-SOAs) are well-known devices with potential in a variety of applications. Recently, they have been used as high-speed logical gates [1], multiwavelength converters [2] or signal regenerators [3], making them one of the key components for future all-optical networks. However, integrated MZI-SOAs with hybrid technology encompass several components (couplers, waveguides, phase shifters and SOAs), all with their own tolerances and asymmetries. These issues lead to a very long and difficult initial setup phase [4], which varies from device to device owing to fabrication and integration yields. An MZI-SOA working characteristic is well described with a static model [5], through which we carry out the operational parameters optimisation and the determination of operational limits exploiting a genetic algorithm (GA).