“…Safety Assessment. From the several indicators that can be used for inherent safety, such as the use of quantitative risk analysis, 21,22 or metrics, such as the Fire and Explosion Damage Index (FEDI) 23,24 or the combination of Process Route Index (PRI) 25 and Process Stream Index (PSI), 26,27 the safety aspects for each heat exchanger are evaluated in this work through the Inherent Safety Index for Shell and Tube Heat Exchangers (ISISTHE) proposed by Pasha et al 19 This index takes into account pressure, heating value, combustibility, and temperature difference for each heat exchanger, related to their average values in the network. For each heat exchanger, a value for each parameter is obtained using eqs 4−7.…”