Inheritance Patterns of Noise Vulnerability and “Protectability” in (C57BL/6J × CBA/J) F1 Hybrid Mice

Barden, Emily Kathleen; Rellinger, Erin A.; Ortmann, Amanda; Ohlemiller, Kevin K.

doi:10.3766/jaaa.23.5.4

Cited by 6 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This comprehensive study design with both positive (noise) and negative (water) controls confirms the findings of many previous studies regarding the severity and consistency of noise-related damage to auditory function (Johnson 1993, Barden et al 2012). For combination treatment, a similar strategy to studies on the interactions of styrene and noise was used (Mäkitie et al 2003; Venet et al 2015).…”

Section: Discussionsupporting

confidence: 86%

Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse

Carlson

Schacht

Neitzel

2018

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

Exposure to heavy metals may lead to hearing impairment. However, experimental studies have not explored this issue with and without noise exposure in mature animals with environmentally relevant doses. The aim of this study was to investigate ototoxicity produced by lead (Pb) and cadmium (Cd) and noise, singly and in combination, in the adult CBA/CaJ mouse. Metals were delivered via drinking water (0.03 mM, 1 mM, and 3 mM Pb; or 30, 100, and 300 μM Cd) for 12 weeks, resulting in environmentally- and occupationally-relevant mean (± standard deviations) blood levels of Pb (2.89 ± 0.44, 38.5 ± 4.9, and 60.1 ± 6.6 μg/dl, respectively) and Cd (1.3 ± 0.23, 6.37 ± 0.87, 27.2 ± 4.1 μg/L, respectively). Metal treatment was also combined with a noise exposure consisting of a 105 dB broadband (2–20 kHz) stimulus for 2 hr or a sham exposure. Auditory performance was determined by comparing auditory brainstem responses (ABR) and otoacoustic emissions (DPOAE) at baseline and after 11 weeks of metal treatment. Metal-exposed animals did not develop significant auditory deficits and did not exhibit morphological damage to cochlear hair cells. In contrast, noise-exposed animals, including those exposed to combinations of metals and noise, demonstrated significant hair cell loss, reduced DPOAE amplitudes, and ABR threshold shifts of 42.2 ± 13 dB at 32 kHz (105 dB noise alone). No significant potentiation or synergistic effects were found in groups exposed to multiple agents. This study establishes a highly reproducible adult mouse model that may be used to evaluate a variety of environmental exposure mixtures.

show abstract

Section: Discussionsupporting

confidence: 86%

Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse

Carlson

Schacht

Neitzel

2018

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

show abstract

“…We used CBA mice which are commonly used in studies of noise-induced hearing loss [54]. Although they have been shown to have increased noise susceptibility compared to C57Bl/6J mice at younger ages, they do not have the age-related hearing loss associated with this strain [55], [56]. As well, other strains of mice have been shown to have even more alterations in noise susceptibility [57].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Hearing Loss after Blast Injury to the Ear

et al. 2013

View full text Add to dashboard Cite

Given the frequent use of improvised explosive devices (IEDs) around the world, the study of traumatic blast injuries is of increasing interest. The ear is the most common organ affected by blast injury because it is the body’s most sensitive pressure transducer. We fabricated a blast chamber to re-create blast profiles similar to that of IEDs and used it to develop a reproducible mouse model to study blast-induced hearing loss. The tympanic membrane was perforated in all mice after blast exposure and found to heal spontaneously. Micro-computed tomography demonstrated no evidence for middle ear or otic capsule injuries; however, the healed tympanic membrane was thickened. Auditory brainstem response and distortion product otoacoustic emission threshold shifts were found to be correlated with blast intensity. As well, these threshold shifts were larger than those found in control mice that underwent surgical perforation of their tympanic membranes, indicating cochlear trauma. Histological studies one week and three months after the blast demonstrated no disruption or damage to the intra-cochlear membranes. However, there was loss of outer hair cells (OHCs) within the basal turn of the cochlea and decreased spiral ganglion neurons (SGNs) and afferent nerve synapses. Using our mouse model that recapitulates human IED exposure, our results identify that the mechanisms underlying blast-induced hearing loss does not include gross membranous rupture as is commonly believed. Instead, there is both OHC and SGN loss that produce auditory dysfunction.

show abstract

“…These types of strains have greatly assisted in identifi cation of novel genetic variants associated with ARHL (Nemoto et al 2004 ;Johnson et al 2012 ). Similar approaches should prove useful to characterize the genetic basis of known strain differences in auditory function, including differences in responses to noise stress , protection from conditioning stresses (Barden et al 2012 ), and aging (Noben-Trauth and Johnson 2009 ;NobenTrauth et al 2010 ;Schacht et al 2012 ).…”

Section: Mouse Modelsmentioning

confidence: 99%

Genes and Hearing Loss: Relationship to Oxidative Stress and Free Radical Formation

Kohrman

2015

Free Radicals in ENT Pathology

View full text Add to dashboard Cite

Inheritance Patterns of Noise Vulnerability and “Protectability” in (C57BL/6J × CBA/J) F1 Hybrid Mice

Cited by 6 publications

References 34 publications

Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse

Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse

Mechanisms of Hearing Loss after Blast Injury to the Ear

Genes and Hearing Loss: Relationship to Oxidative Stress and Free Radical Formation

Contact Info

Product

Resources

About