“…A variety of factors, including gene mutations that affect lens metabolism are closely associated with cataract (J. Li, Chen, Yan, & Yao, 2020), and autosomal dominant congenital cataract is the most common mode of inheritance (Berry, Georgiou, et al, 2020). To date, mutations in at least 50 genes involved in lens structure and development have been linked to isolated congenital cataract (Berry, Ionides, et al, 2020;Shiels & Hejtmancik, 2017), including crystallin genes (CRYAA, CRYAB, CRYBB1, CRYBB2, CRYBB3, CRYBA1/A3, CRYBA2, CRYBA4, CRYGC, CRYGD and CRYGS) (Bhat, 2003;Zhuang et al, 2019), membrane protein genes (GJA3, GJA8, MIP and LIM2) (Berry, Francis, Kaushal, Moore, & Bhattacharya, 2000;Beyer, Ebihara, & Berthoud, 2013;Pei et al, 2020), growth and transcription factor genes (PITX3, MAF and HSF4) (Anand, Agrawal, Slavotinek, & Lachke, 2018), beaded filament structural protein genes (BFSP1 and BFSP2) (Song et al, 2009) and other genes (CHMP4B and EPHA2) (Dave et al, 2016;Shiels et al, 2007).…”