Inherited Dental Anomalies: A Review and Prospects for the Future Role of Clinicians

Pemberton, Trevor J.; Mendoza, Gustavo Garrido; Gee, Jason; Patel, Pragna I.

doi:10.1080/19424396.2007.12221232

Cited by 6 publications

(1 citation statement)

References 91 publications

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“…If epidermal EMP+ basal cells are homologous with mammalian ameloblasts, we reasoned that in addition to genes encoding matrix proteins, these cells should express transcription factors that regulate mammalian ameloblast differentiation. Indeed, we find that dlx3a , dlx4a , msx2a , and runx2b are expressed in these cells ( Figure 3B ; Pemberton et al, 2007 ; Debiais-Thibaud et al, 2011 ; Urzúa et al, 2011 ; Bae et al, 2018 ; Chu et al, 2018 ; Woodruff et al, 2022 ; Li et al, 2011b ). Together, these results suggest that the enamel-like, hypermineralized limiting layer of the scale is produced by deeply conserved, ameloblast-like epidermal cells.…”

Section: Resultsmentioning

confidence: 82%

Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

Aman

Saunders

Carr

et al. 2023

eLife

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Pigment patterns and skin appendages are prominent features of vertebrate skin. In zebrafish, regularly patterned pigment stripes and an array of calcified scales form simultaneously in the skin during post-embryonic development. Understanding mechanisms that regulate stripe patterning and scale morphogenesis may lead to discovery of fundamental mechanisms that govern development of animal form. To learn about cell types and signaling interactions that govern skin patterning and morphogenesis we generated and analyzed single cell transcriptomes of skin from wild-type fish as well as fish having genetic or transgenically induced defects in squamation or pigmentation. These data reveal a previously undescribed population of epidermal cells that express transcripts encoding enamel matrix proteins, suggest hormonal control of epithelial-mesenchymal signaling, clarify the signaling network that governs scale papillae development, and identify a critical role for the hypodermis in supporting pigment cell development. Additionally, these comprehensive single-cell transcriptomic data representing skin phenotypes of biomedical relevance should provide a useful resource for accelerating discovery of mechanisms that govern skin development and homeostasis.

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Section: Resultsmentioning

confidence: 82%

Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

Aman

Saunders

Carr

et al. 2023

eLife

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Prevalência e distribuição de dentes supranumerários numa população pediátrica – Um estudo radiográfico

Coelho

Macho

Andrade

et al. 2011

Revista Portuguesa de Estomatología, Medicina Dentária e Cirugi

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Multiple Dental Inclusion in Monozygotic Twins with Congenital Visual Impairment

Galluccio

Impellizzeri

Stefano

et al. 2020

Case Reports in Dentistry

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The study presents two monozygotic twins (MZ) with multiple impacted teeth, affecting the upper canines and lower second molars, as well as congenital aniridia. The clinical aspect of the upper canines is peculiar because of the different positions—palatal in one and buccal in the other twin. Studies reporting different scenarios of impaction in monozygotic twins can contribute more data to the debate on tooth eruption aetiology and more so in this case because of the association with a genetic panocular disease. Patients’ Concerns. The patients were referred by a general dentist, who diagnosed the presence of multiple inclusions. Diagnostic Study. Both patients showed severe malocclusion, classified as grade 5 of the Index of Orthodontic Treatment Need (IOTN). The MZ showed class I malocclusion, upper and lower crowding, and impacted lower right and left second molars. A Dentascan was prescribed for the canine impaction. The impaction of the upper canine was palatal of 2.3 in one of the MZ and buccal of 1.3 in the other one. The same altered pattern of eruption of the lower second molars was identified in both twins. The proposed treatment plan contemplated orthodontic surgical recovery of the impacted elements, followed by orthodontic treatment with multibracket appliance after the extraction of the first four premolars, given the crowding entity. The use of a retraction spring action was chosen for the recovery of the lower second molars. Many aspects of the possible genetic aetiology of tooth impaction are still under discussion. The study of diseases in twins offers decisive information. Finally, the possibility that alterations in the eruptive pattern of the dental elements may be associated with other congenital problems broadens the range of investigations related to the possible aetiological causes of the inclusions in humans.

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Inherited Dental Anomalies: A Review and Prospects for the Future Role of Clinicians

Cited by 6 publications

References 91 publications

Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin

Prevalência e distribuição de dentes supranumerários numa população pediátrica – Um estudo radiográfico

Multiple Dental Inclusion in Monozygotic Twins with Congenital Visual Impairment

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