Inherited Disorders in Danish Cattle

Agerholm, Jørgen Steen

doi:10.1111/j.1600-0463.2007.apm_v115_s122.x

Cited by 36 publications

(23 citation statements)

References 161 publications

(178 reference statements)

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“…Affected animals are identified at slaughter by their discolored kidneys, justifying the more common designation of 'black kidney disease' . RL is not accompanied by gross renal dysfunction, yet it may cause more insidious deleterious effects, as evidenced by a reduced longevity of affected animals 7,8 . The incidence of RL was estimated at 0.44% in HolsteinFriesian and 2.5% in Danish Red breeds.…”

mentioning

confidence: 99%

Highly effective SNP-based association mapping and management of recessive defects in livestock

et al. 2008

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mentioning

confidence: 99%

Highly effective SNP-based association mapping and management of recessive defects in livestock

et al. 2008

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“…Studies have suggested the role of inheritance of a simple recessive gene in the development of lipofuscinosis (Duffell and Edwardson 1978;Hayward 1978;Agerholm 2007;Agerholm et al 2009). A higher prevalence of the condition is confirmed in Ayrshire cattle than other breeds of cattle (Duffell and Edwardson 1978;Hayward 1978).…”

Section: Discussionmentioning

confidence: 86%

Bovine generalized lipofuscinosis and sarcoplasmic inclusions: histopathological and histochemical features in three cases

Ohfuji¹

2015

Comp Clin Pathol

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Three adult Holstein-Friesian dairy cows (4 to 6 years old) which had been raised at three different farms were culled with a long history of locomotor dysfunction attributed to dislocation or subluxation of the hip joint (two cows) or foot rot (one cow). They revealed dark brown discoloration of multiple sites of the carcasses at postmortem examination. On histopathological and histochemical investigations, lipofuscin pigments showing autofluorescence, sudanophilia, argyrophilia, periodic acid-Schiff (PAS) positiveness, and acid fastness were stored within otherwise normal cells of various sites in the body, including many thoracic and abdominal viscera, skeletal muscle, diaphragm, and tongue. In the central nervous system, some neurons with massive lipofuscin deposition were prominently shrunken but associated with neither necrotic changes nor glial reaction. Such a generalized pigmentary condition was distinguished from neuronal ceroid lipofuscinosis and thus was diagnosed as generalized lipofuscinosis. Furthermore, distinct proteinaceous eosinophilic inclusions were simultaneously observed to a varying degree within myofibers of the diaphragm, heart, rumen, or small intestine. These inclusions stained weakly positive with PAS and negative with Nile blue, Sudan black B, periodic acid-methenamine silver (PAM), and acid-fast stains. Autofluorescence was not seen. Staining properties demonstrated by phosphotungstic acid-hematoxylin (purple blue) and Masson's trichrome (bright red) stains were compatible with those of myofibrils, presumably suggesting that the inclusions have chemical composition similar or identical to that of myofibrils. It remains to be elucidated whether the occurrence of such sarcoplasmic inclusions was related to lipofuscinogenesis or a nonspecific phenomenon indicating an incidental finding.

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“…This demands the necessity of including survival traits in the selection criteria when recruiting sires for production traits. Genotyping of animals by genomic analysis has efficiently reduced the prevalence of bovine leukocyte adhesion deficiency, complex vertebral malformation and spinal dysmyelination [5]. Moreover, Donagh et al reported that selection for increased milk production alone without any cognizance of other trait is expected to increase the incidence of mastitis, lameness, cystic ovaries, ketosis and metritis [6].…”

Section: Sire Effectmentioning

confidence: 99%

“…Holstein cows are susceptible to specific genetic disorders. Jørgen reported that chondrodysplasia, complex vertebral malformation, syndrome of artheogyropsis and acroteriasis caused abortion and stillbirths while bovine progressive degeneration myeloencephlopathy, spinal muscular atrophy and osteognesis imperfeta resulted in calf mortality [5].…”

Section: Distribution Of Cows According To Daughters Reached To Produmentioning

confidence: 99%

Genetics of Threshold Characters and Distribution Cow Calving Traits in Holstein Friesian Cattle at Holeta Bull Dam Station, Ethiopia

Goshu¹

2017

J Vet Sci Technol

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Data collected from at Holeta Bull Dam Station from 118 sires and 902 dams were used to asses distribution of threshold traits as affected by sire variance and calving traits cows. The traits studied were type of birth (normal, abnormal), sex ratio, and female calves reached to age at first calving. Variance analyses were made to estimate effect of sire variances and repeatability of cows on the above threshold traits. The result showed that from the total of 1223 female births, 67.7% reached to productive age. Sire affected type of birth (P<0.05), sex ratio (P<0.01), and female calves reaching to productive age (P<0.0001). The distribution of calf production traits of cows showed that 30.8% of cows calved only once, 27.7% calved abnormal births at least once in their life time and 27.3% left the herd without producing any female progeny. The probability of a cow repeating abnormal birth, given the previous birth was abnormal, was very high (0.96). It is commendable to test semen for genetic disorder other than milk yield trait to expand dairy production in the country. The number of female calves reaching to productive age can be increased through introduction of sound reproductive management and improving survivability of calves.

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Inherited Disorders in Danish Cattle

Cited by 36 publications

References 161 publications

Highly effective SNP-based association mapping and management of recessive defects in livestock

Highly effective SNP-based association mapping and management of recessive defects in livestock

Bovine generalized lipofuscinosis and sarcoplasmic inclusions: histopathological and histochemical features in three cases

Genetics of Threshold Characters and Distribution Cow Calving Traits in Holstein Friesian Cattle at Holeta Bull Dam Station, Ethiopia

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