Inherited Hypertension in Rats

Smirk, F. H.; Hall, William H.

doi:10.1038/182727a0

Cited by 195 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 " 8 The use of these animal models, especially the spontaneously hypertensive rat (SHR) of Okamoto and Aoki, 4 is widespread in hypertension research. This use has usually not met its full potential because of a failure to include genetic techniques in the analysis of biochemical and physiological traits.…”

mentioning

confidence: 99%

A paradigm for identification of primary genetic causes of hypertension in rats.

Rapp¹

1983

Hypertension

View full text Add to dashboard Cite

A paradigm is developed for identifying the genes (and the biochemical-physiological traits for which the genes code) that cause differences in blood pressure in inbred strains of rats. A biochemical-physiological trait which meets the following four criteria is one which can reasonably be accepted as causing genetic differences in blood pressure: 1) a difference in a biochemical or physiological trait between two strains must be demonstrated; 2) the trait must be shown to follow Mendelian inheritance; 3) the genes identified in criterion 2 must co-segregate with an increment in blood pressure which is significantly different from zero; and 4) there must be some logical biochemical and/or physiological link between the trait and blood pressure. Traits which do not show discrete phenotypes following Mendelian inheritance may correlate with blood pressure in segregating populations. In this case no rigorous cause and effect genetic argument is possible because such correlations could arise from complex primary genetic causes or as secondary effects of blood pressure on the biochemical-physiological trait.

show abstract

mentioning

confidence: 99%

A paradigm for identification of primary genetic causes of hypertension in rats.

Rapp¹

1983

Hypertension

View full text Add to dashboard Cite

show abstract

“…Since the description of inbred hypertensive strains in the rat [113,114], it has never been identified what trait actually is inbred which later manifests itself as hypertension. The present hypothesis proposes for the first time that the said trait in the SHR is the increased renal EGFR expression continued from infancy to adulthood [8,9].…”

Section: Increased Renal Egfr Expression As a Genetic Traitmentioning

confidence: 99%

A Single Initiating Cause of Hypertension; Potential for Primary Prevention

Sambhi¹

2014

J Hypertens

View full text Add to dashboard Cite

“…He is also credited with the development, by selective inbreeding, of laboratory rats with inherited hypertension. 47 The greatest coup of his career as research administrator, however, was to secure £120,000 from the Initially, however, the war years did not make it easy to establish a functioning laboratory in Dunedin. There was hardly any equipment and much had to be improvised, supplies were unreliable, and there was not much space for Smirk and his staff.…”

Section: Therapeutic Enthusiasmmentioning

confidence: 99%

Hexamethonium, Hypertension and Pharmaceutical Innovation: The Transformation of an Experimental Drug in Post-war Britain

Timmermann¹

2006

Devices and Designs

View full text Add to dashboard Cite

Inherited Hypertension in Rats

Cited by 195 publications

References 0 publications

A paradigm for identification of primary genetic causes of hypertension in rats.

A paradigm for identification of primary genetic causes of hypertension in rats.

A Single Initiating Cause of Hypertension; Potential for Primary Prevention

Hexamethonium, Hypertension and Pharmaceutical Innovation: The Transformation of an Experimental Drug in Post-war Britain

Contact Info

Product

Resources

About