Inherited thrombophilia and in vitro fertilization implantation failure

Colaizzo, Donatella; Bue, A. Lo; Checola, Maria Gabriella; Cittadini, E; Margaglione, Maurizio

doi:10.1016/s0015-0282(01)01832-5

Cited by 99 publications

(70 citation statements)

References 4 publications

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“…Current literature has conflicting findings in relation to the role of thrombophilia and its impact on repeat IVF failure. While some studies have suggested that repeat IVF failure may be associated with an increased incidence of thrombophilia [37][38][39][40][41] others have negated such an association [42][43][44]. In a recent systemic review and metaanalysis, pooled data from patients in 8 case control studies showed an overall 3-fold increased risk of ART failure in association with factor V Leiden; while in the 3 cohort studies there was no difference in outcome between those with and those without factor V Leiden mutation [45].…”

Section: Discussionmentioning

confidence: 99%

Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

Younis

Ben‐Ami

Izhaki

et al. 2013

J Assist Reprod Genet

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Purpose In the last few years more robust evidence is emerging to point out at an increased rate of prematurity and low birth weight in singleton pregnancies following ART. Whether this increased rate is related to ART practice or to infertility per se, is still an open question. Our aim in this study was to explore this question by evaluating Protein C (ProC) Global assay in infertile women before ART treatment. Methods A cohort of 95 unselected and consecutive infertile women, eligible for ART, was prospectively recruited for the study. The control group included 77 matched healthy fertile women with a history of spontaneous conceptions. Pro C Global assay was evaluated in both groups. A full thrombophilic work-up was performed in the study group.Results ProC Global assay level was found to be significantly lower in the study as compared to the control group, corresponding to 0.78 ± 0.16 and 0.88 ± 0.16, respectively (P <0.01). As well, abnormal ProC Global assay level of ≤0.8 was significantly higher in the study as compared to control group corresponding to 53 % and 29 %, respectively. ProC Global assay level was significantly lower in women within the study group found to have APCR, factor V Leiden and high factor VIII level, any thrombophilia or combined thrombophilia when compared to women without these thrombophilic risk factors. Conclusions Reduced ProC Global assay level is encountered in infertile women prior to ART treatment. This finding may suggest a unique anticoagulation Protein C pathway in infertile as compared to fertile women. Further studies are encouraged to explore this finding.

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Section: Discussionmentioning

confidence: 99%

Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

Younis

Ben‐Ami

Izhaki

et al. 2013

J Assist Reprod Genet

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“…Although the thrombophilic state, either inherited or acquired, has been mainly associated with repeated pregnancy loss, several investigators have reported an association between RIF and a tendency for hypercoagulable conditions [7,43]. It is assumed that the mechanism of implantation failure is similar to that of pregnancy loss, namely, disturbed blood flow to the endometrium and placenta.…”

Section: Thrombophiliamentioning

confidence: 99%

Assessment and treatment of repeated implantation failure (RIF)

Simon

Laufer

2012

J Assist Reprod Genet

215

161

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Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

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“…[68]. The study includes a small number of women with more than 3 failed IVF attempts (n=18) compared with 216 women with at least one successful terminated pregnancy.…”

Section: Advantages and Disadvantages Of Fvl During Implantationmentioning

confidence: 99%