Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India

Abstract

The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.

Recurrent pregnancy loss: can factor V Leiden mutations be a cause

“…Only few studies have analyzed the prevalence of FVL mutations in the Indian population and the associated risk of RPL. One study that included 40 cases reported a 10% prevalence of FVL mutation in cases of RPL [11]. However, the study was limited by the fact that a control group was not included in the study, making it difficult to estimate the risk of association.…”

Placental Pathology and Stillbirth: A Review of the Literature and Guidelines for the Less Experienced

“…However, maternal vascular malperfusion may also be seen in inherited thrombophilias which have a recognised association with stillbirth [23]. Whilst the prevalence of these thrombophilias in the Indian population has not been extensively investigated, screening for these conditions may help complete the investigations and provide treatment options in the next pregnancy [24,25]. (Fig.…”