Inherited thrombophilias and pre-eclampsia in Brazilian women

Dusse, Luci Maria Sant’Ana; Carvalho, Maria das Graças; Bragança, William Fialho; Paiva, Sabrina Guimarães; Godói, Lara Carvalho; Guimarães, Daniela Amorim Melgaço; Fernandes, Ana Paula

doi:10.1016/j.ejogrb.2006.09.006

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…Livingston et al [20] did not detect a higher prevalence of thrombophilia in black patients with severe preeclampsia compared with controls. Also, lack of association of FVL and prothrombin G20210A mutations with preeclampsia has been reported in other populations including American-Indians [21], Scottish [22], Netherlands [4], Canadian [23] and Brazilian [24,25]. In addition, among American-European [26], British [5], Italian [27] and Mexican [28] the FVL mutation was not associated with the risk of preeclampsia.…”

Section: Discussionmentioning

confidence: 92%

Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

Malek-Khosravi

Rahimi

et al. 2011

J Thromb Thrombolysis

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The aim of the present study was to investigate the frequency and the possible association between thrombophilic mutations of factor V Leiden (FVL) and prothrombin G20210A with preeclampsia among Kurdish population of Western Iran. We studied 198 women with preeclampsia including 128 women with mild and 70 women with severe forms and 101 healthy pregnant women with uncomplicated pregnancy. Among cases there were 23 women with early onset preeclampsia and 175 cases with late-onset preeclampsia. The sample was genotyped by polymerase chain reaction-restriction fragment-length polymorphism using Mnl I and Hind III for FVL and prothrombin G20210A, respectively. The frequency of heterozygous FVL mutation was 7.6% among all preeclamptic women (8.6% in mild and 5.7% in severe preeclamptic women) and 7.9% in controls (P > 0.05). However, the prevalence of heterozygous FVL were 10.5 and 3.9% among severe preeclamptic women with early onset and late-onset preeclampsia, respectively (P > 0.05). The prevalence of prothrombin G20210A were 1.6, 2.9, and 3% among women with mild preeclamsia, severe preeclampsia and controls, respectively (P > 0.05). The level of serum triglycerides (TG) was significantly higher among women with preeclampsia compared to healthy pregnant women that was not associated with the two thrombophilic mutations. Our results indicate that neither FVL nor prothrombin G20210A could be a risk factor for preeclampsia in our population. However, high prevalence of FVL in preeclamptic women with early onset compared to those with late-onset preeclampsia may suggest a role for this mutation in predisposition to early onset preeclampsia that need to be confirmed with larger sample size.

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Section: Discussionmentioning

confidence: 92%

Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

Malek-Khosravi

Rahimi

et al. 2011

J Thromb Thrombolysis

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“…Two studies [28], [36] were excluded because of the absence of FVL in either patient or control groups, one of which identified this SNP in a Japanese population[28]. With regard to ethnic background, it was difficult to identify the ethnic origin of individuals in three studies [24], [31], [34], which were therefore excluded. Ultimately 37 studies were included in our meta-analysis, with 23 studies evaluating the PT 20210 polymorphism and 35 analyzing the FVL.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of disease definition, the criteria of the American College of Obstetricians and Gynecologists [13] and the National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy [14] were mostly used, in 13 [10], [15]–[26] and 6 [9], [27]–[31] studies, respectively, among which the definitions of preeclampsia and severe preeclampsia varied little. In these studies, preeclampsia was defined as systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg, with the presence of proteinuria by 24-h urinary excretion exceeding 300 mg after 20 weeks of gestation.…”

Section: Methodsmentioning

confidence: 99%

Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

et al. 2014

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ObjectiveTo estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP.Date SourcesA systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included “preeclampsia,” “thrombophilia,” “factor V Leiden,” “prothrombin gene 20210,” and their combinations.Result(s)Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25–2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06–4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28–2.00) and 2.45 (95%CI 1.63–3.69) for the cases of severe preeclampsia.Conclusion(s)This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.

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“…However, Leiden mutation was not present in both investigated groups. Three heterozygote carriers of PTM were detected in control group (3.61 vs. 0.0% in preeclamptic women) [26]. Similarly, in Netherlands study the differences in the frequency of six genetic factors between preeclamptic and healthy pregnant women (157 cases/157 controls) has not been found [27].…”

Section: Discussionmentioning

confidence: 90%

The significance of genetic polymorphisms of factor V leiden and prothrombin in the preeclamptic polish women

Seremak‐Mrozikiewicz

Drews

Wender-Ożegowska

et al. 2009

J Thromb Thrombolysis

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Many studies established that gestational hypertension (GH) and preeclampsia (PE) are multifactorial diseases and disturbances in coagulation cascade have etiological significance. Inherited thrombophilias, like polymorphism of factor V (FV) Leiden and prothrombin (PTM) are considered to be involved in the PE development. The aim of this study was to determine the association between FV Leiden and G20210A of PTM gene polymorphism and GH/PE appearance. The study comprised 235 women: GH (n = 126, mean age 27.5 +/- 6.0 years), mild PE (n = 41, mean age 28.3 +/- 5.7 years), and severe PE (n = 68, mean age 28.5 +/- 5.7 years). The control group consisted of 400 healthy pregnant women (mean age 27.5 +/- 4.7 years). All women included in the study were white Caucasian of Polish origin, and were singleton pregnancies. The G1691A polymorphism of FV and G20210A polymorphism of PTM were detected using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assays. For PTM G20210A polymorphism overrepresentation of heterozygous GA genotype (7.4 vs. 1.2%, P = 0.02) and of A allele (3.7 vs. 0.6%, P = 0.02) in the group of severe PE have been found. For FV G1691A polymorphism the overrepresentation of genotypes containing at least one mutated allele A (GA and AA) in the group of women with mild (9.7 vs. 3.5%, ns) and severe PE (8.8 vs. 3.5%, ns) was observed. Our results suggest the significant influence of G20210A prothrombin polymorphism and possible influence of G1691A factor V polymorphism in the development of severe preeclampsia.

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Inherited thrombophilias and pre-eclampsia in Brazilian women

Cited by 19 publications

References 32 publications

Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

The significance of genetic polymorphisms of factor V leiden and prothrombin in the preeclamptic polish women

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