Inhibin A and B levels in serum and follicular fluids of women with various reproductive failures undergoing in vitro fertilization

Babcová, K; Z, Ulcová-Gallová; Rumpík, David; Micanova, Zdenka; Bibková, K

doi:10.17772/gp/57844

Cited by 3 publications

(2 citation statements)

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“…Women with endometriosis demonstrate higher levels of activin than unaffected controls (Cahill & Hull, 2000 ; Reis et al, 2012 ; Rombauts et al, 2006 ) and giving activin to mice promotes endometriotic lesion growth (Kasai et al, 2019 ). Conversely, women with PCOS are characterized by lower activin (Eldar‐Geva et al, 2001 ; Norman et al, 2001 ) and higher inhibin (Babćová et al, 2015 ; Tsigkou et al, 2008 ), compared with controls.…”

Section: Resultsmentioning

confidence: 99%

Endometriosis and polycystic ovary syndrome are diametric disorders

Dinsdale

Crespi

2021

Evolutionary Applications

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Evolutionary and comparative approaches can yield novel insights into human adaptation and disease. Endometriosis and polycystic ovary syndrome (PCOS) each affect up to 10% of women and significantly reduce the health, fertility, and quality of life of those affected. PCOS and endometriosis have yet to be considered as related to one another, although both conditions involve alterations to prenatal testosterone levels and atypical functioning of the hypothalamic-pituitary-gonadal (HPG) axis. Here, we propose and evaluate the novel hypothesis that endometriosis and PCOS represent

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Section: Resultsmentioning

confidence: 99%

Endometriosis and polycystic ovary syndrome are diametric disorders

Dinsdale

Crespi

2021

Evolutionary Applications

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“…Jump FSH values occurs as a result of the negative feedback FSH-modulating ovarian proteins, mainly inhibin A and inhibin B. Since the Inhibin B (dimeric polypeptide secreted by ovarian granulosa cells) is predominantly secreted in the early antral follicles, decrease in the value of inhibin B in serum directly indicates a decrease in antral follicles "pull" in the ovaries (12).…”

Section: Introductionmentioning

confidence: 99%

Decline in Female Fertility After 40 Years

Sorak

Sazdanović

Tulić³

et al. 2018

Serbian Journal of Experimental and Clinical Research

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Important factor related to the conception possibility is women age. The decline in fertility with aging is proven and evident in literature. Infertility is increasing and many couples seek help in advanced techniques such as IVF (in vitro fertilization) in order to overcome the problem caused by aging, but the quality of the oocytes is a significant limiting factor. With the aging the quantity and quality of oocytes decreases, such as the quality of the embryo after fertilization. The accelerated rhythm of life, liberty and women inclusion in all kinds of professions brought many benefits to women, but also increasingly postponing births. Each person is unique individual, and can be more or less fertile compared to the average at same age. Unfortunately, some women has a rapid decline in fertility - accelerate aging, very early, already in the early twenties and when testing them with different methods and exams, the result is very low number of oocytes, low value of anti-Müllerian hormone and also very poor quality of these oocytes, or low ovarian reserve. The problem is that when you have accelerate aging, even IVF techniques can not be of great help in achieving pregnancy. The pregnancy rate (17,65%) and the childbirth rate (5,88%) with the patients older than 40 is very low, although comparable to the data from the scientific literature and speaks in favour of the fact that the success of assisted reproductive techniques is very modest with women older than 44.

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