Inhibin: New Gonadal Hormone

Franchimont, P; Demoulin, Alain; Verstraelen-Proyard, J.; Hazee-Hagelstein, M. T.; Bourguignon, J P

doi:10.1007/978-94-009-8875-0_2

Cited by 4 publications

(8 citation statements)

References 29 publications

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“…The concomitant effect on LH levels was either nonexistent or minimal. The suppressive effect of 3rd V inhibin on FSH values required 2-4 h to be demonstrable, 6-8 h to reach its maximum effect and lasted at least 10 h. Such a time course is similar to that of other studies in which inhibin preparations were administered systemically to rodents (2,11).…”

Section: Discussionmentioning

confidence: 51%

“…Inhibin was purified from the rete testis fluid (RTF) of rams according to procedures described elsewhere (2,5,Franchimont et_ al_.,in press). Briefly, RTF extracts were subjected to gel filtration on Sephadex G 100, isotachophoresis on acrylamidebisacrylamide gel, electrophoresis in SDS polyacrylamide gel, dialysis, and lyophilization to yield three inhibin fractions for testing: RTF 38-1, RTF 38-11, and RTF LA.…”

Section: Methodsmentioning

confidence: 99%

“…Immediately after withdrawing a pre-treatment blood sample (0.5 ml), 30 yg of RTF 38-I or saline were microinjected into the 3rd V of orchidectomized (ORDX) animals. Additional blood samples were obtained 1,2,4,6,8,10 and 24 h following injection for determination of gonadotropin levels in plasma. Experiment 2.…”

Section: Methodsmentioning

confidence: 99%

“…Since that time, FSH-inhibiting substances have been purified from numerous gonadal components of both male and female mammals. Preparations of ram rete testis fluid (2,3), bull (4) and human (2,5) seminal plasma, bovine (6) and porcine (7) follicular fluid and rat Stertoli (8) and granulosa (9) cells have exhibited an inhibin-like activity. The inhibition of FSH release by these substances is usually selective, or at least preferential, when compared to their generally lesser influence over LH secretion.…”

Section: In 1932 Mccullaghmentioning

confidence: 99%

“…The inhibition of FSH release by these substances is usually selective, or at least preferential, when compared to their generally lesser influence over LH secretion. The action of inhibin is exerted at the pituitary gland to suppress both basal and LHRH-stimulated FSH release both in vivo (5,10,11) and in vitro (5,8,12). Preliminary evidence obtained from in vitro experiments (13) also suggests that inhibin has an ability to reduce hypothalamic LHRH content, but direct evidence that inhibin reduces circulating FSH levels in vivo via a hypothalamic site of action is still Tacking.…”

mentioning

confidence: 99%

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Evidence for a Hypothalamic Site of Action of Inhibin to Suppress FSH Release*

et al. 1981

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To determine if inhibin has a hypothalamic site of action to suppress FSH release, highly purified inhibin preparations from the rete testis fluid (RTF) of rams were injected into adult male rats which had been orchidectomized (ORDX) 24 hours earlier. Third ventricular (3rd V) injection of a potent inhibin fraction (RTF 38-I) significantly depressed plasma FSH concentrations, without influencing LH, 4-10 h after treatment. A less active preparation of inhibin (RTF 38-II) at the same dose had no effect. A higher dose of another less potent fraction (RTF 1A) significantly reduced FSH 2-6 h following 3rd V administration, accompanied by slight but significant decrements in LH at 2 and 4 only. To determine responsiveness of the pituitary, luteinizing hormone-releasing hormone (LHRH) was injected intravenously at 6 h. It induced similar elevations of FSH and LH in inhibin- and saline-treated groups. Systemic administration of RTF 38-II at a dose 2.5-fold higher than the dose effective centrally failed to modify either FSH or LH levels up to 6 h. These results provide evidence that inhibin from the male can preferentially suppress FSH release by a CNS site of action in addition to its well-known pituitary site of action.

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Section: Discussionmentioning

confidence: 51%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: In 1932 Mccullaghmentioning

confidence: 99%

mentioning

confidence: 99%

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Evidence for a Hypothalamic Site of Action of Inhibin to Suppress FSH Release*

et al. 1981

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Recovery from Severe Oligospermia After Exposure to Dibromochloropropane

Lantz

Cunningham

Huckins

et al. 1981

Fertility and Sterility

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Evaluation of Steroids as COntraceptives in Men

Foegh¹

1983

Acta Endocrinologica

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At the time this study was initiated in 1974, the most attractive approach to male contraception in view of the success with the female oral contraceptive was by use of steroids, since coitus interruptus, sperm-barrier methods and vasectomy have major drawbacks in terms of either psychological stress, inconvenience or irreversibility. Of particular concern is the high failure rate of the first two methods. Moreover, contemporary society requires a male contraceptive, like that for the female, not only to be effective, but also safe, easily used and, in contrast to vasectomy, readily reversible. An attractive feature of a reversible oral contraceptive is the potential for minimizing potential side effects due to alternation of contraception between partners.However, an overriding concern in developing an oral contraceptive for men, who are not as motivated as strongly as women, is a wide margin of safety. Furthermore, in women, the risk of contraception is compared to the risk of pregnancy and abortion; while in men, the risk has to be

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Inhibin: New Gonadal Hormone

Cited by 4 publications

References 29 publications

Evidence for a Hypothalamic Site of Action of Inhibin to Suppress FSH Release*

Evidence for a Hypothalamic Site of Action of Inhibin to Suppress FSH Release*

Recovery from Severe Oligospermia After Exposure to Dibromochloropropane

Evaluation of Steroids as COntraceptives in Men

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