Inhibiting Activity of Estrogens on Capillary Permeability

Hemostasis by Premedication with Estrogen in Hair‐Transplant Surgery

“…This phenomenon is particularly pronounced in the basal membranes of small vessels and in the perivascular tissue. In sum, a decrease in vascular and perivascular permeability results and reduces capillary bleeding. Estrogens have also been shown to decrease hemorrhage induced by certain snake venoms.…”

The effect of Premarin on blood loss attending open heart surgery

“…It has been suggested that the administration of Prernarin may reduce blood loss in patients following open intracardiac operations (Ambrus et al, 1971) and adenoidectomy (Menger, 1955). Premarin, a conjugated oestrogen substance, has been reported to cause an increase in Factors 1V and V levels (Johnson, 1957;Wayne et al, 1964) and in platelet aggregation (Elkeles et al, 1968), and to decrease capillary permeability (Maki et al, 1969) and circulating fibrinolytic activity in man (Villadolid et al, 1965).…”