2024
DOI: 10.1101/2024.08.22.609220
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Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy

Eun Young Jeon,
Yejin Kwak,
Hyeji Kang
et al.

Abstract: Duchenne muscular dystrophy (DMD) is a devastating X-linked disorder caused by mutations in the dystrophin gene. Despite recent advances in understanding the disease etiology and applying emerging treatment methodologies, glucocorticoid derivatives remain the only general therapeutic option that can slow disease development. However, the precise molecular mechanism of glucocorticoid action remains unclear, and there is still need for additional remedies to complement the treatment. Here, using single-nucleus R… Show more

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