Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations
Zhen‐Guo Zhang,
Hong‐Mei Zhu,
Huai‐Kang Hua
Abstract:ObjectiveThis study aimed to investigate the role of Interleukin‐11 receptor alpha (IL11RA) in skin cutaneous melanoma (SKCM) metastasis to the liver.MethodsHuman SKCM cell lines (A375, A375‐MA2, SK‐MEL‐28, RPMI‐7951) and primary dermal fibroblasts (HDFa) were utilized to assess IL11RA expression. IL11RA siRNA was transfected into RPMI‐7951 and A375‐MA2 cells for Wound healing and Transwell invasion assays. Il11ra knockout (KO) mice and wild‐type (WT) mice were injected with B16‐F10 cells into the spleen to ev… Show more
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