Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes

Yu, Xinhe; Gao, Duo; Gao, Liquan; Lai, Jianhao; Zhang, Chenran; Zhao, Yanping; Zhong, Liang; Jia, Bing; Wang, Fan; Chen, Xiaoyuan; Liu, Zhaofei

doi:10.1021/acsnano.7b04736

Cited by 174 publications

(130 citation statements)

References 62 publications

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“…We are glad to see that a study has exploited an αvβ6 integrin-specific peptide to generate a tumor-targeted photosensitizer, which, when used in photodynamic therapy, resulted in effective ablation of primary lung tumors in mouse models. 50 In conclusion, our studies suggest that BSP expression could influence the αvβ3 integrin level in breast cancer cells. The αvβ3 integrin could partly reverse the decreased effect of bone metastasis caused by IBSP gene silencing.…”

Section: Discussionmentioning

confidence: 58%

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

Wang

Song²,

Li³

et al. 2019

Cancer Science

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The underlying mechanisms of breast cancer cells metastasizing to distant sites are complex and multifactorial. Bone sialoprotein (BSP) and αvβ3 integrin were reported to promote the metastatic progress of breast cancer cells, particularly metastasis to bone. Most theories presume that BSP promotes breast cancer metastasis by binding to αvβ3 integrin. Interestingly, we found the αvβ3 integrin decreased in BSP silenced cells (BSPi), which have weak ability to form bone metastases. However, the relevance of their expression in primary tumor and the way they participate in metastasis are not clear. In this study, we evaluated the relationship between BSP, αvβ3 integrin levels, and the bone metastatic ability of breast cancer cells in patient tissues, and the data indicated that the αvβ3 integrin level is closely correlated to BSP level and metastatic potential. Overexpression of αvβ3 integrin in cancer cells could reverse the effect of BSPi in vitro and promote bone metastasis in a mouse model, whereas knockdown of αvβ3 integrin have effects just like BSPi. Moreover, The Cancer Genome Atlas data and RT‐PCR analysis have also shown that SPP1, KCNK2, and PTK2B might be involved in this process. Thus, we propose that αvβ3 integrin is one of the downstream factors regulated by BSP in the breast cancer‐bone metastatic cascade.

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Section: Discussionmentioning

confidence: 58%

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

Wang

Song²,

Li³

et al. 2019

Cancer Science

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“…A safe and effective immunotherapy with great controllability and sensitivity can be achieved by developing novel drug delivery platforms based on nanotechnology and material science. [264][265][266][267][268][269][270] The cascaded synergistic effects of photodynamic-immunotherapy can provide a promising strategy to inhibit both primary lesions and distant metastases, which can be hardly achieved by conventional PDT with limited immunologic effects. [256] Moreover, the combination of immunotherapy and PDT has attracted an increasing attention due to the potential systematic antitumor immunity after PDT.…”

Section: Postoperative Immunotherapy For Long-term Antitumor Effectsmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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“…Tumor cells undergoing apoptosis or necrosis release tumor-associated antigens. 108 Recent studies have found that the hypoxia state in the tumor microenvironment affected not only the PDT efficiency but also the antitumor immunity. 2).…”

Section: Recent Advance Of Nanoparticle-based Pdtmentioning

confidence: 99%

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

Hou

Tao

Pang

et al. 2018

Intl Journal of Cancer

190

123

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Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. The antitumor effects can be enhanced by immune checkpoint blockage therapy. This article reviewed the recent advances of nanoparticle-based PTT and PDT, summarized the studies on nanoparticle-based photothermal and photodynamic immunotherapies in vitro and in vivo, and discussed challenges and future research directions.

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Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes

Cited by 174 publications

References 62 publications

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

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