2012
DOI: 10.1101/lm.025148.111
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Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior

Abstract: Evidence suggests that two regions of the striatum contribute differential support to instrumental response selection. The dorsomedial striatum (DMS) is thought to support expectancy-mediated actions, and the dorsolateral striatum (DLS) is thought to support habits. Currently it is unclear whether these regions store task-relevant information or just coordinate the learning and retention of these solutions by other brain regions. To address this issue, we developed a two-lever concurrent variable-interval rein… Show more

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Cited by 43 publications
(44 citation statements)
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“…The trend toward greater LTP in DM relative to DL striatum is maintained whether or not GABA A is blocked (Smith et al 2001); and our use of picrotoxin rules out regional differences in plasticity of GABA A transmission. Whatever the reasons for greater LTP magnitude and duration dorsomedially, the current utility of TBS LTP in either region (albeit reduced laterally) will be valuable for investigating learning, since dorsal striatal regions serve distinct styles and phases of learning (Pauli et al 2012;.…”
Section: Discussionmentioning
confidence: 99%
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“…The trend toward greater LTP in DM relative to DL striatum is maintained whether or not GABA A is blocked (Smith et al 2001); and our use of picrotoxin rules out regional differences in plasticity of GABA A transmission. Whatever the reasons for greater LTP magnitude and duration dorsomedially, the current utility of TBS LTP in either region (albeit reduced laterally) will be valuable for investigating learning, since dorsal striatal regions serve distinct styles and phases of learning (Pauli et al 2012;.…”
Section: Discussionmentioning
confidence: 99%
“…Striatal activity is critical for instrumental learning (Graybiel 1995;Yin et al 2005), motor skill development (Yin et al 2009), cued action-selection (Packard and Teather 1997), and habit formation . Distinct types and stages of learning differ in their engagement of medial and lateral dorsal striatal regions (Pauli et al 2012;. Observations in vivo and ex vivo suggest that changes in strength of connection between neurons underlie striatal learning and memory (Koralek et al 2012;Pascoli et al 2011;Pauli et al 2012;Shen et al 2011;Yin et al 2009).…”
mentioning
confidence: 99%
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“…For example, converging evidence suggests a division of labor between the ventral striatum (VS) and dorsal striatum for Pavlovian and instrumental conditioning, respectively (20,21). Within the dorsal striatum, medial regions support behavioral flexibility and lateral regions support well-learned behavior (22,23). This work has greatly advanced our understanding of the similarities of striatal function in human and nonhuman animals.…”
mentioning
confidence: 94%
“…PKMζ also contributes to maintaining the structural modifications of dendritic spines and synapses (Chen et al., 2014, Shao et al., 2012), changes that have been extensively observed in the sensorimotor cortex after sensorimotor learning (Yu and Zuo, 2011). Inhibition of persistent aPKC activity in specific brain structures by zeta inhibitory peptide (ZIP) disrupts the maintenance of various types of memory, including hippocampus-dependent spatial memory (Pastalkova et al., 2006), basolateral amygdala-dependent fear memories (Gámiz and Gallo, 2011, Kwapis et al., 2012, Kwapis et al., 2009, Migues et al., 2010, Serrano et al., 2008), dorsal lateral striatum-dependent habit memory (Pauli et al., 2012), and insular cortex-dependent long-term associative conditioned taste aversion memory (Shema et al., 2007), as well as sensorimotor cortex-dependent motor learning in the reaching task (von Kraus et al., 2010). However, ZIP affects PKC isoforms in addition to PKMζ, particularly the other aPKC, PKCι/λ, which can compensate for PKMζ in PKMζ-knockout mice (Tsokas et al., 2016).…”
Section: Introductionmentioning
confidence: 99%