Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Nie, Shen; Cui, Xiaoya; Guo, Jinping; Ma, Xiaojie; Zhi, Haijun; Li, Shilei; Yong, Li

doi:10.1002/jcb.27440

Cited by 3 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have demonstrated that multiple indicators play crucial roles in detecting patients at risk for SAP and the development of complications. These indicators include serum amylase (AMY) [8], lipase (LIP) [9], low serum ionized calcium (Ca 2+ ) [10], high-sensitivity C-reactive protein (hsCRP) [11], neutrophil-lymphocyte ratio (NLR) [12,13], and BMI [14][15][16]. However, to the best of our knowledge, the changes in these clinic parameters in patients with HTGP have not been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Jin

et al. 2019

Med Sci Monit

View full text Add to dashboard Cite

Background To investigate the clinical characteristics of hypertriglyceridemia pancreatitis (HTGP) and evaluate the correlative risk factors for severe acute pancreatitis (SAP) in HTGP patients. Material/Methods A total of 1005 patients with acute pancreatitis (AP) admitted to Peking Union Medical College Hospital (PUMCH) from 1 Jan 2013 to 1 Aug 2018 were retrospectively reviewed. After screening, we enrolled 159 patients with HTGP and 172 with non-hypertriglyceridemia pancreatitis (NHTGP). We gathered and assessed demographic and blood biochemical information and analyzed the risk factors for SAP. Results Age, serum amylase (AMY), lipase (LIP), and serum ionized calcium (Ca 2+ ) in the HTGP group were lower than in the NHTGP group ( P <0.05), while high-sensitivity C-reactive protein (hsCRP), neutrophil–lymphocyte ratio (NLR), and body mass index (BMI) in the HTGP group were higher than in the NHTGP group ( P <0.05). Among the HTGP patients, the results indicated that Ca 2+ (OR=0.018, P <0.001, 95%CI: 0.002–0.129) was an independent protective factor for SAP, while higher CRP (OR=1.008, P =0.004, 95%CI: 1.003–1.013), NLR (OR=1.314, P <0.001, 95%CI: 1.161–1.488), and BMI (OR=1.597, P =0.002, 95%CI: 1.195–2.314) were independent risk factors for SAP. Conclusions Patients with HTGP had lower serum Ca 2+ and higher hsCRP, NLR, and BMI, and these were associated with higher risk of developing SAP.

show abstract

Section: Introductionmentioning

confidence: 99%

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Jin

et al. 2019

Med Sci Monit

View full text Add to dashboard Cite

show abstract

Long-chain fatty acids - The turning point between ‘mild’ and ‘severe’ acute pancreatitis

Liu,

Gu,

Liu

et al. 2024

Heliyon

View full text Add to dashboard Cite

Protective effects of Baicalin injection on severe acute pancreatitis through regulating follistatin-like-1 signaling pathway by down-regulating miR-429 expression in mice

Yang

Liu

et al. 2022

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Abstract: Rosiglitazone could protect mice with SAP from injury by downregulating Socs3 and inhibiting the inflammatory response pathway.

Cited by 3 publications

References 27 publications

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Long-chain fatty acids - The turning point between ‘mild’ and ‘severe’ acute pancreatitis

Protective effects of Baicalin injection on severe acute pancreatitis through regulating follistatin-like-1 signaling pathway by down-regulating miR-429 expression in mice

Contact Info

Product

Resources

About