Inhibiting tumor oxygen metabolism and simultaneously generating oxygen by intelligent upconversion nanotherapeutics for enhanced photodynamic therapy

Wang, Dan; Xue, Bin; Ohulchanskyy, Tymish Y.; Liu, Yubin; Yakovliev, Artem; Ziniuk, Roman; Xu, Mengze; Song, Jun; Qu, Junle

doi:10.1016/j.biomaterials.2020.120088

Cited by 61 publications

(43 citation statements)

References 57 publications

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“…The use of enzymes that produce oxygen within the tumor itself has also been proposed. These include naturally occurring enzymes such as catalase and nanozymes such as MnO 2 and CuO ( Chen et al, 2018 ; Sharma et al, 2018 ; Yu et al, 2019 ; Wang et al, 2020 ; Yang et al, 2020 ). However, all these approaches face major challenges, including low efficiency of oxygen production, premature oxygen leakage, and inadequate tumor microvessels.…”

Section: Introductionmentioning

confidence: 99%

“…While some studies have been done to utilize targeting and immune evasion capacity of platelet membrane and starvation therapy for tumor therapy, Pan developed a DOX-loaded platelet-inspired nanovehicles to enhance cell-specific targeting. Li studied a mCGP system to realize amplified synergistic therapeutic effects of starvation therapy and photodynamic therapy ( Wang et al, 2020 ). But they only used platelet membrane targeting alone, or coordinated starvation therapy with photodynamic therapy, without further amplifying starvation therapy.…”

Section: Introductionmentioning

confidence: 99%

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Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang

Chang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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The restriction of a tumor’s energy supply is proven to be an effective means of treatment. Glucose oxidase (GOx), an enzyme that catalyzes the conversion of glucose to glucolactone, producing oxygen and hydrogen peroxide in the process, has proved useful in this regard. However, hypoxia, which is implicated in tumor growth, has been found to mediate resistance to this type of tumor starvation. Here, we describe the design and testing of a platelet membrane mimetic, PMS, consisting of mesoporous silica nanoparticles (MSNs) loaded with metformin (MET) as an inner layer and platelet membranes (PM) as an outer layer that inhibits oxygen consumption by the tumor cells’ respiratory pathways and enhances the effectiveness of GOx. MET directly inhibits the activity of complex I in mitochondrial electron transport and is thus a potent inhibitor of cell respiration. PMS target tumor tissue effectively and, once internalized, MET can inhibit respiration. When oxygen is plentiful, GOx promotes glucose consumption, allowing amplification of its effects on tumor starvation. This combination of respiratory suppression by PMS and starvation therapy by GOx has been found to be effective in both targeting tumors and inhibiting their growth. It is hoped that this strategy will shed light on the development of next-generation tumor starvation treatments.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Huang

Chang

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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“…This endows the Yb-based nanoparticles with a more effective treatment property, achieving the integration of diagnosis and therapy easily. The group of Yuan described an integrated platform including photosensitizer Ce6 and Yb-based upconversion coreshell nanostructures 34 . Ce6 was activated by the light emitted by unconversion nanostructures under the irradiation of NIR laser and produced reactive oxygen species for deep phototherapy.…”

Section: Ytterbium-based Nanoparticlesmentioning

confidence: 99%

Nanoparticles: Untying the Gordian Knot in Conventional Computed Tomography Imaging

Sun

et al. 2021

CCS Chem

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X-ray computed tomography (CT) imaging plays an essential role in disease diagnosis due to its noninvasive, painless mode, and superior penetration depth.However, the resolution of the soft tissue and minor lesions remains limited. And the disadvantages of conventional contrast agents, such as inefficient targeting capability, poor biocompatibility, and short circulation times, are considered intractable in clinical using. To overcome these "Gordian Knot", nanoparticles for CT imaging have been developed to achieve the purposes that people aspire to. The advantages of nanoparticles are excepted high sensitivity to X-ray and better imaging performance in vivo, even therapeutic effect. In particular, based on the various design, nanoparticle contrast agents composed of different materials integrate multiple imaging modalities, make up the inadequacy of a single imaging type, and thus provide more accurate information for diagnosis. This review focus on the nanoparticles for X-ray CT imaging, and of which the multi-functional designs. Some perspectives of crucial problems and prospective challenges are also further discussed.

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“…In the presence of light, O 2 in the tissues can also be converted by direct energy transfer into the highly toxic 1 O 2 (type II PSs). [186] The mechanism of type II PSs depends on the 1 O 2 produced by the PSs during irradiation and may lead to tumor cell necrosis or apoptosis. [187] However, as O 2 is consumed, insufficient O 2 levels can seriously affect their therapeutic effects.…”

Section: Nanocatalystsmentioning

confidence: 99%

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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With the rapid advancements in nanotechnology and materials science, numerous nanomaterials have been used as catalysts for nanomedical applications. Their design and modification according to the microenvironment of diseases have been shown to achieve effective treatment. Chemists are in pursuit of nanocatalysts that are more efficient, controllable, and less toxic by developing innovative synthetic technologies and improving existing ones. Recently, single-atom catalysts (SACs) with excellent catalytic activity and high selectivity have attracted increasing attention because of their accurate design as nanomaterials at the atomic level, thereby highlighting their potential for nanomedical applications. In this review, the recent advances in nanocatalysts and SACs are briefly summarized according to their synthesis, characterizations, catalytic mechanisms, and nanomedical applications. The opportunities and future scope for their development and the issues and challenges for their application as nanomedicine are also discussed. As far as it is known, the review is the systematic comparison of nanocatalysts and SACs, especially in the field of nanomedicine, which has promoted the development of nanocatalytic medicine.

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Inhibiting tumor oxygen metabolism and simultaneously generating oxygen by intelligent upconversion nanotherapeutics for enhanced photodynamic therapy

Cited by 61 publications

References 57 publications

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor

Nanoparticles: Untying the Gordian Knot in Conventional Computed Tomography Imaging

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

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