Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex

Urquiza, N.; Islas, María Soledad; Dittler, María Laura; Moyano, María Alejandra; Manca, S. G.; Lezama, Luís; Rojo, Teófilo; Medina, Juan José Martínez; Diez, Maximiliano; Tévez, Leonor López; Williams, Patricia Ana María; Ferrer, Evelina G.

doi:10.1016/j.ica.2013.05.022

Cited by 33 publications

(18 citation statements)

References 71 publications

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“…aeruginosa than [Cu(pr‐norf)(bipyam)Cl] and [Cu(PPA)(phen)Cl] reported by Efthimiadou et al . and [Cu‐phen], [Cu‐Met] and [Cu‐Met‐phen] reported by Urquiza et al …”

Section: Resultsmentioning

confidence: 78%

Synthesis, spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents

Mehta

Gajera

Patel

et al. 2015

Applied Organom Chemis

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*Seven new copper(II) complexes of type [Cu(A)(L)]ÁH 2 O (A = sparfloxacin, ciprofloxacin, levofloxacin, gatifloxacin, pefloxacin, ofloxacin, norfloxacin; L = 5-[(3-chlorophenyl)diazenyl]-4-hydroxy-1,3-thiazole-2(3H)-thione) were synthesized and characterized using elemental and thermogravimetric analyses, and electronic, electron paramagnetic resonance (EPR), Fourier transform infrared and liquid chromatography-mass spectroscopies. Tetrahedral geometry around copper is assigned in all complexes using EPR and electronic spectral analyses. All complexes were investigated for their interaction with herring sperm DNA utilizing absorption titration (K b = 1.27-3.13 × 10 5 M À1) and hydrodynamic volume measurement studies. The studies suggest the classical intercalative mode of DNA binding. The cleavage reaction on pUC19 DNA was monitored by agarose gel electrophoresis. The results indicate that the Cu(II) complexes can more effectively promote the cleavage of plasmid DNA. The superoxide dismutase mimic activity of the complexes was evaluated by nitroblue tetrazolium assay, and the complexes catalysed the dismutation of superoxide at pH = 7.8 with IC 50 values in the range 0.597-0.900 μM. The complexes were screened for their in vitro antibacterial activity against five pathogenic bacteria. All the complexes are good cytotoxic agents and show LC 50 values ranging from 5.559 to 11.912 μg ml À1. All newly synthesized Cu(II) complexes were also evaluated for their in vitro antimalarial activity against Plasmodium falciparum strain (IC 50 = 0.62-2.0 μg ml À1).

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“…aeruginosa than [Cu(pr‐norf)(bipyam)Cl] and [Cu(PPA)(phen)Cl] reported by Efthimiadou et al . and [Cu‐phen], [Cu‐Met] and [Cu‐Met‐phen] reported by Urquiza et al …”

Section: Resultsmentioning

confidence: 78%

Synthesis, spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents

Mehta

Gajera

Patel

et al. 2015

Applied Organom Chemis

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“…Hence, changes of cell permeability can be detected by measuring changes of ALP activity. Cell wall and membrane are important protective barriers for microorganisms to keep normal life activities . Antimicrobial substances may cause leaking out of macromolecular materials in bacterial cells such as carbohydrates, proteins, and nucleic acids.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activities of Sophorolipids and Nisin and Their Combination against Foodborne Pathogen Staphylococcus aureus

Chen

Zhi-fei

et al. 2019

Euro J Lipid Sci & Tech

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In food processing, both preservatives and surfactants are usually added to ensure the quality of food. Sophorolipids (SLs) are extracellular biosurfactants produced by yeasts that have antibacterial activities. Nisin is a polycyclic antibacterial peptide produced by Lactococcus lactis. In this study, the possibility of using SLs alone as a preservative and in combination with nisin as a compound additive is investigated. SLs and nisin exhibit effective antibacterial activities against foodborne pathogen Staphylococcus aureus with minimum inhibitory concentrations of 32 and 0.5 µg mL−1, respectively. Both SLs and nisin increase cell wall and cell membrane permeability of S. aureus, enhance intracellular content release and activities of extracellular ALP and β‐galactosidase, and reduce respiratory‐chain dehydrogenase activity of the pathogen. Fractional inhibitory concentration (FIC) index for SLs and nisin combination is 1.5, indicating the effect of SLs with nisin is additive. Results of the study indicate that SLs could be used alone as a preservative or in combination with nisin as a promising compound additive with functions of both emulsifier and preservative. Practical Applications: SLs could be used alone as a preservative in food industry or in combination with nisin as a promising compound additive with functions of both emulsifier and preservative.

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“…It has been reported that some coumarinic derivatives [49] and some metal complexes of HCCA have antimicrobial effects [2]. Hence, we propose to study the activity of the binary and ternary complexes, in addition to HCCA, phen, and Zn(II) for comparative purposes against different The activities for Zn(II) and phen have previously been reported by our group [52].…”

Section: Microbiological Assaysmentioning

confidence: 89%

“…According to the chelating character of phen, ALP activity decreases due to complexation of Zn(II) from the active site [47]. This inhibition is relatively low at 100 M, however it increases in a significant manner at 10 time higher concentrations, with an inhibition of ALP activity of 59 % at 1 mM [49].…”

Section: Accepted Manuscript 23mentioning

confidence: 99%

Comparisons of the spectroscopic and microbiological activities among coumarin-3-carboxylate, o-phenanthroline and zinc(II) complexes

Islas¹,

Medina

Piro

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Coumarins (2H-chromen-2-one) are oxygen-containing heterocyclic compounds that belong to the benzopyranones family. In this work we have synthesized different coordination complexes with coumarin-3-carboxylic acid (HCCA), o-phenanthroline (phen) and zinc(II). In the reported [Zn(CCA)(HO)] complex, coumarin-3-carboxylate (CCA) is acting as a bidentate ligand while in the two prepared complexes, [Zn(phen)]CCA(NO) (obtained as a single crystal) and [Zn(CCA)phen].4HO, CCA is acting as a counterion of the complex cation [Zn(phen)] or coordinated to the metal center along with phen, respectively. These compounds were characterized on the basis of elemental analysis and thermogravimetry. NMR, FTIR and Raman spectroscopies of the compounds and the CCA potassium salt (KCCA) allow to determine several similarities and differences among them. Finally, their behavior against alkaline phosphatase enzyme and their antimicrobial activities were also measured.

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Inhibition behavior on alkaline phosphatase activity, antibacterial and antioxidant activities of ternary methimazole–phenanthroline–copper(II) complex

Cited by 33 publications

References 71 publications

Synthesis, spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents

Synthesis, spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents

Antibacterial Activities of Sophorolipids and Nisin and Their Combination against Foodborne Pathogen Staphylococcus aureus

Comparisons of the spectroscopic and microbiological activities among coumarin-3-carboxylate, o-phenanthroline and zinc(II) complexes

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