1964
DOI: 10.1136/ard.23.1.78
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Inhibition by 6-Mercaptopurine of Polyarthritis induced by Freund's Adjuvant

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1964
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Cited by 36 publications
(13 citation statements)
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“…When a purine antagonist, 6-mercaptopurine, was administered to patients with systemic lupus erythematosus the responses were equivocal (Lee, Meiselas, Zingale, and Richman (1961). The development of adjuvant-induced arthritis in rats has been successfully inhibited by 6-mercaptopurine (Kalliomaki, Saarimaa, and Toivanen, 1964). Methotrexate has been used experimentally in psoriatic arthritis (O'Brien, Van Scott, Black, Eisen, and Bunim, 1962; Scott, Auerbach, Eisen, and Bunim, 1964).…”
mentioning
confidence: 99%
“…When a purine antagonist, 6-mercaptopurine, was administered to patients with systemic lupus erythematosus the responses were equivocal (Lee, Meiselas, Zingale, and Richman (1961). The development of adjuvant-induced arthritis in rats has been successfully inhibited by 6-mercaptopurine (Kalliomaki, Saarimaa, and Toivanen, 1964). Methotrexate has been used experimentally in psoriatic arthritis (O'Brien, Van Scott, Black, Eisen, and Bunim, 1962; Scott, Auerbach, Eisen, and Bunim, 1964).…”
mentioning
confidence: 99%
“…Suppression of adjuvant-induced polyarthritis by 6-mercaptopurine has been demonstrated by several groups of investigators (6,14,28). It has not been established, however, whether the drug suppresses adjuvant arthritis by virtue of its immunosuppressive or its antiinflammatory properties, or both.…”
Section: Discussionmentioning
confidence: 99%
“…A causal relationship between suppression of the cell-mediated immune response and suppression of arthritis development has been suggested by Kalliomaki et al (14) and by Perper et a1 (28) based on the observations that the drug brought about a simultaneous inhibition of the development of adjuvant arthritis and delayed dermal hypersensitivity to tuberculin. On the other hand, Ward et al (6) reported that 6-mercaptopurine (25-100 mg/kg IM or IP) suppressed or prevented the development of adjuvant arthritis without altering either the humoral or the cellular hypersensitivity to old tuberculin.…”
Section: Discussionmentioning
confidence: 99%
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“…However, the exact mechanism of the development of secondary lesions are still uncertain. Reports have shown that the dissemination and processing of adjuvant components is involved in the induction of AA (Kalliomaki et al 1964 ;Newbould 1964;Waksman et al 1960).…”
mentioning
confidence: 99%